Home / People / Faculty / Kang Zhao

Kang Zhao——Professor

Room 453, Building 11, Tianjin University
School of Pharmaceutical Science and Technology
Group weblink
Education Experience
1988 Ph. D. Columbia University, NY, USA
1988 Postdoctoral Columbia University, NY, USA
Professional Experience
2001-2015 Professor Tianjin University
2001-2003 Dean Tianjin University
2001-2003 Director TEDA, Tianjin
1995-1999 Professor W. M. Keck Foundation Early
1990-1992 Fellow Columbia Univ
Research Area

The research in the group of Zhao is encompassed in 4 main areas, including 1) Medicinal Chemistry:  Design and synthesis of drug molecules, and development of synthetic route to drug intermediates, 2) Biological Organic Chemistry:  Investigation of anti-cocaine, monoclonal antibodies, and anti-viruses, 3) Organic Synthetic Methodology: Hypervalent iodine chemistry and heterocyclic chemistry, and 4) Total Synthesis of Complex Molecules: design and synthesis of natural products.


Honors and Awards
杜云飞,马辉,赵康,异吲哚啉羧酸酯衍生物的制备方法及其应用,中国,201 010187238.1。
杜云飞,汤丽娜,庞永乐,阎俏,祁秀香,一种合成Coumestan类衍生物的新方 法,中国,201010171129.0。
祁秀香,杜云飞,闫俏,赵康,李慧,合成N-芳基吲哚-3-腈衍生物的方法,中 国,201010560853.2。
杜云飞,云希柳,毕文英,赵康,一种氮取代四氢咔唑酮衍生物的制备新方法 ,中国,201010252043.0。
杜云飞,赵康,赵菲菲,刘昕,齐蕊,2-三氟甲基噁唑类衍生物的合成方法, 中国,201110120698.7。
杜云飞,刘乐,贺巧巧,赵康,1,3-二腈基2-取代-1H-茚类衍生物及其制备方 法,中国,201210044059.1。
杜云飞,吕晶磊,尚巳耘,赵康,一种四氢-γ-咔啉类衍生物的合成方法,中 国,201310022038.4。
杜云飞,李旭明,张翔,赵康,一种二苯西平类衍生物的合成方法,中国,2013 10455049.1。
杜云飞,吕晶磊,赵康,一种2-吲哚酮-3-羧酸酯类衍生物的合成方法,中国,2 01310503250.2。
杜云飞,尚巳耘,赵康,一种合成二苯并二氢-1,3-二氮杂䓬类衍生物的方法, 中国,201310608894.8。
杜云飞,程然,赵康,一种通过环合消除一锅法合成4(3H)-喹唑啉酮衍生物的 方法,中国,201410113565.0。
杜云飞,程然,赵康,一种通过环合消除一锅法合成4(3H)-喹唑啉酮衍生物的 方法,中国,201410113565.0。
杜云飞,袁玉成,赵康,一种通过C–N氧化偶联合成取代二氨基烯烃衍生物的方 法,中国,2014104793464
Highlighted Publications
Shang, S.; Zhang-Negrerie, D.; Du, Y.; Zhao, K. Intramolecular Metal-free Oxidative Aryl-aryl Coupling: An Unusual Hypervalent Iodine-mediated Rearrangement of 2-Substituted N-Phenylbenzamides. Angew. Chem., Int. Ed. 2014, 53, 6216 (Hot Paper).
Liu, L.; Lu, H.; Wang, H.; Yang, C.; Zhang, X.; Zhang-Negrerie, D.; Du, Y.; Zhao, K. PhI(OCOCF3)2-Mediated C-C Bond Formation Concomitant with a 1,2-Aryl Shift in a Metal-Free Synthesis of 3-Arylquinolin-2-ones. Org. Lett. 2013, 15, 2906.
Du, Y.-F.; Liu, R.-H.; Linn, G.; Zhao, K. Synthesis of N-Substituted Indole Derivatives via PIFA-Mediated Intramolecular Cyclization. Org. Lett. 2006, 8, 5919.
Landry, D. W.; Zhao, K.; Yang, G. X. Q.; Glickman, M; Georgiadis, T. M. Antibody-Catalyzed Degradation of Cocaine. Science 1993, 259, 1899.
Stork, G.; Zhao, K. Total Synthesis of (-)-Histrionicotoxin and (-)-Histrionicotoxin 235A. J. Am. Chem. Soc. 1990, 112, 5875.
ResearcherID Publications
Year Title Author(s) Source Volume
2014 Organocatalytic amination of alkyl ethers via n-Bu4NI/t-BuOOH-mediated intermolecular oxidative C(sp(3))-N bond formation: novel synthesis of hemiaminal ethers Dian, Longyang; Wang, Sisi; Zhang-Negrerie, Daisy; et al. Chemical Communications 50
2014 Metal-Free Tandem Oxidative Aryl Migration and C-C Bond Cleavage: Synthesis of alpha-Ketoamides and Esters from Acrylic Derivatives Liu, Le; Du, Liang; Zhang-Negrerie, Daisy; et al. Organic Letters 16
2014 Metal-Free Synthesis of 2-Oxindoles via PhI(OAc)(2)-Mediated Oxidative C-C Bond Formation Lv, Jinglei; Zhang-Negrerie, Daisy; Deng, Jun; et al. Journal of Organic Chemistry 79
2014 Hypervalent Iodine-Mediated Oxygenation of N,N-Diaryl Tertiary Amines: Intramolecular Functionalization of sp(3) C-H Bonds Adjacent to Nitrogen Zhang, Ningning; Cheng, Ran; Zhang-Negrerie, Daisy; et al. Journal of Organic Chemistry 79
2014 Intramolecular Metal-Free Oxidative Aryl-Aryl Coupling: An Unusual Hypervalent-Iodine-Mediated Rearrangement of 2-Substituted N-Phenylbenzamides Shang, Siyun; Zhang-Negrerie, Daisy; Du, Yunfei; et al. Angewandte Chemie-International Edition 53
2014 Direct Oxidative Coupling of Enamines and Electron-Deficient Amines: TBAI/TBHP-Mediated Synthesis of Substituted Diaminoalkenes under Metal-Free Conditions Yuan, Yucheng; Hou, Wenjuan; Zhang-Negrerie, Daisy; et al. Organic Letters 16
2015 Synthesis of Chromeno[2,3-b]indol-11(6H)-one via PhI(OAc)(2)-Mediated Intramolecular Oxidative C(sp(2))-N(H-2) Bond Formation Sun, Jiyun; Zhang-Negrerie, Daisy; Du, Yunfei; et al. Journal of Organic Chemistry 80
2014 Construction of 1,4-Benzodiazepine Skeleton from 2-(Arylamino)benzamides through Phl(OAc)(2)-Mediated Oxidative C-N Bond Formation Li, Xuming; Yang, Liu; Zhang, Xiang; et al. Journal of Organic Chemistry 79
2015 A convenient synthesis of indoloquinolinones via 3-arylation of indole-2-carboxamides and PIDA-mediated C-N bond formation Li, Yulin; Zhang-Negrerie, Daisy; Du, Yunfei; et al. Tetrahedron 71
2015 PhI(OCOCF3)(2)-Mediated Cyclization of o-(1-Alkynyl)benzamides: Metal-Free Synthesis of 3-Hydroxy-2,3-dihydroisoquinoline-1,4-dione Yang, Chao; Zhang, Xiang; Zhang-Negrerie, Daisy; et al. Journal of Organic Chemistry 80