Home / People / Faculty / Kang Zhao

Kang Zhao——Professor

Nationality:
USA
Phone:
022-27404031
Email:
kangzhao@tju.edu.cn
Office:
Room 453, Building 11, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1988 Ph. D. Columbia University, NY, USA
1988 Postdoctoral Columbia University, NY, USA
Professional Experience
2001-2015 Professor Tianjin University
2001-2003 Dean Tianjin University
2001-2003 Director TEDA, Tianjin
1995-1999 Professor W. M. Keck Foundation Early
1990-1992 Fellow Columbia Univ
Research Area

The research in the group of Zhao is encompassed in 4 main areas, including 1) Medicinal Chemistry:  Design and synthesis of drug molecules, and development of synthetic route to drug intermediates, 2) Biological Organic Chemistry:  Investigation of anti-cocaine, monoclonal antibodies, and anti-viruses, 3) Organic Synthetic Methodology: Hypervalent iodine chemistry and heterocyclic chemistry, and 4) Total Synthesis of Complex Molecules: design and synthesis of natural products.

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Honors and Awards
杜云飞,四乙酰核糖和二乙酰阿昔洛韦合成的新工艺,天津市人民政府,科技进步奖,二等奖,2010。(赵康、陈维瑜、魏静、杜云飞、王松青、苏艳芳、张秀东、陈炎泉)
Patents
杜云飞,马辉,赵康,异吲哚啉羧酸酯衍生物的制备方法及其应用,中国,201 010187238.1。
杜云飞,汤丽娜,庞永乐,阎俏,祁秀香,一种合成Coumestan类衍生物的新方 法,中国,201010171129.0。
祁秀香,杜云飞,闫俏,赵康,李慧,合成N-芳基吲哚-3-腈衍生物的方法,中 国,201010560853.2。
杜云飞,云希柳,毕文英,赵康,一种氮取代四氢咔唑酮衍生物的制备新方法 ,中国,201010252043.0。
杜云飞,赵康,赵菲菲,刘昕,齐蕊,2-三氟甲基噁唑类衍生物的合成方法, 中国,201110120698.7。
杜云飞,刘乐,贺巧巧,赵康,1,3-二腈基2-取代-1H-茚类衍生物及其制备方 法,中国,201210044059.1。
杜云飞,吕晶磊,尚巳耘,赵康,一种四氢-γ-咔啉类衍生物的合成方法,中 国,201310022038.4。
杜云飞,李旭明,张翔,赵康,一种二苯西平类衍生物的合成方法,中国,2013 10455049.1。
杜云飞,吕晶磊,赵康,一种2-吲哚酮-3-羧酸酯类衍生物的合成方法,中国,2 01310503250.2。
杜云飞,尚巳耘,赵康,一种合成二苯并二氢-1,3-二氮杂䓬类衍生物的方法, 中国,201310608894.8。
杜云飞,程然,赵康,一种通过环合消除一锅法合成4(3H)-喹唑啉酮衍生物的 方法,中国,201410113565.0。
杜云飞,程然,赵康,一种通过环合消除一锅法合成4(3H)-喹唑啉酮衍生物的 方法,中国,201410113565.0。
杜云飞,袁玉成,赵康,一种通过C–N氧化偶联合成取代二氨基烯烃衍生物的方 法,中国,2014104793464
Highlighted Publications
Shang, S.; Zhang-Negrerie, D.; Du, Y.; Zhao, K. Intramolecular Metal-free Oxidative Aryl-aryl Coupling: An Unusual Hypervalent Iodine-mediated Rearrangement of 2-Substituted N-Phenylbenzamides. Angew. Chem., Int. Ed. 2014, 53, 6216 (Hot Paper).
Liu, L.; Lu, H.; Wang, H.; Yang, C.; Zhang, X.; Zhang-Negrerie, D.; Du, Y.; Zhao, K. PhI(OCOCF3)2-Mediated C-C Bond Formation Concomitant with a 1,2-Aryl Shift in a Metal-Free Synthesis of 3-Arylquinolin-2-ones. Org. Lett. 2013, 15, 2906.
Du, Y.-F.; Liu, R.-H.; Linn, G.; Zhao, K. Synthesis of N-Substituted Indole Derivatives via PIFA-Mediated Intramolecular Cyclization. Org. Lett. 2006, 8, 5919.
Landry, D. W.; Zhao, K.; Yang, G. X. Q.; Glickman, M; Georgiadis, T. M. Antibody-Catalyzed Degradation of Cocaine. Science 1993, 259, 1899.
Stork, G.; Zhao, K. Total Synthesis of (-)-Histrionicotoxin and (-)-Histrionicotoxin 235A. J. Am. Chem. Soc. 1990, 112, 5875.
ResearcherID Publications
Year Title Author(s) Source Volume
2014 Organocatalytic amination of alkyl ethers via n-Bu4NI/t-BuOOH-mediated intermolecular oxidative C(sp(3))-N bond formation: novel synthesis of hemiaminal ethers Dian, Longyang; Wang, Sisi; Zhang-Negrerie, Daisy; et al. Chemical Communications 50
2014 Metal-Free Tandem Oxidative Aryl Migration and C-C Bond Cleavage: Synthesis of alpha-Ketoamides and Esters from Acrylic Derivatives Liu, Le; Du, Liang; Zhang-Negrerie, Daisy; et al. Organic Letters 16
2014 Metal-Free Synthesis of 2-Oxindoles via PhI(OAc)(2)-Mediated Oxidative C-C Bond Formation Lv, Jinglei; Zhang-Negrerie, Daisy; Deng, Jun; et al. Journal of Organic Chemistry 79
2014 Hypervalent Iodine-Mediated Oxygenation of N,N-Diaryl Tertiary Amines: Intramolecular Functionalization of sp(3) C-H Bonds Adjacent to Nitrogen Zhang, Ningning; Cheng, Ran; Zhang-Negrerie, Daisy; et al. Journal of Organic Chemistry 79
2014 Intramolecular Metal-Free Oxidative Aryl-Aryl Coupling: An Unusual Hypervalent-Iodine-Mediated Rearrangement of 2-Substituted N-Phenylbenzamides Shang, Siyun; Zhang-Negrerie, Daisy; Du, Yunfei; et al. Angewandte Chemie-International Edition 53
2014 Direct Oxidative Coupling of Enamines and Electron-Deficient Amines: TBAI/TBHP-Mediated Synthesis of Substituted Diaminoalkenes under Metal-Free Conditions Yuan, Yucheng; Hou, Wenjuan; Zhang-Negrerie, Daisy; et al. Organic Letters 16
2015 Synthesis of Chromeno[2,3-b]indol-11(6H)-one via PhI(OAc)(2)-Mediated Intramolecular Oxidative C(sp(2))-N(H-2) Bond Formation Sun, Jiyun; Zhang-Negrerie, Daisy; Du, Yunfei; et al. Journal of Organic Chemistry 80
2014 Construction of 1,4-Benzodiazepine Skeleton from 2-(Arylamino)benzamides through Phl(OAc)(2)-Mediated Oxidative C-N Bond Formation Li, Xuming; Yang, Liu; Zhang, Xiang; et al. Journal of Organic Chemistry 79
2015 A convenient synthesis of indoloquinolinones via 3-arylation of indole-2-carboxamides and PIDA-mediated C-N bond formation Li, Yulin; Zhang-Negrerie, Daisy; Du, Yunfei; et al. Tetrahedron 71
2015 PhI(OCOCF3)(2)-Mediated Cyclization of o-(1-Alkynyl)benzamides: Metal-Free Synthesis of 3-Hydroxy-2,3-dihydroisoquinoline-1,4-dione Yang, Chao; Zhang, Xiang; Zhang-Negrerie, Daisy; et al. Journal of Organic Chemistry 80