Home / People / Faculty / Kang Zhao

Kang Zhao——Professor

Nationality:
USA
Phone:
022-27404031
Email:
kangzhao@tju.edu.cn
Office:
Room 453, Building 11, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1988 Ph. D. Columbia University, NY, USA
1988 Postdoctoral Columbia University, NY, USA
Professional Experience
2001-2015 Professor Tianjin University
2001-2003 Dean Tianjin University
2001-2003 Director TEDA, Tianjin
1995-1999 Professor W. M. Keck Foundation Early
1990-1992 Fellow Columbia Univ
Research Area

The research in the group of Zhao is encompassed in 4 main areas, including 1) Medicinal Chemistry:  Design and synthesis of drug molecules, and development of synthetic route to drug intermediates, 2) Biological Organic Chemistry:  Investigation of anti-cocaine, monoclonal antibodies, and anti-viruses, 3) Organic Synthetic Methodology: Hypervalent iodine chemistry and heterocyclic chemistry, and 4) Total Synthesis of Complex Molecules: design and synthesis of natural products.

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Honors and Awards
杜云飞,四乙酰核糖和二乙酰阿昔洛韦合成的新工艺,天津市人民政府,科技进步奖,二等奖,2010。(赵康、陈维瑜、魏静、杜云飞、王松青、苏艳芳、张秀东、陈炎泉)
Patents
杜云飞,马辉,赵康,异吲哚啉羧酸酯衍生物的制备方法及其应用,中国,201 010187238.1。
杜云飞,汤丽娜,庞永乐,阎俏,祁秀香,一种合成Coumestan类衍生物的新方 法,中国,201010171129.0。
祁秀香,杜云飞,闫俏,赵康,李慧,合成N-芳基吲哚-3-腈衍生物的方法,中 国,201010560853.2。
杜云飞,云希柳,毕文英,赵康,一种氮取代四氢咔唑酮衍生物的制备新方法 ,中国,201010252043.0。
杜云飞,赵康,赵菲菲,刘昕,齐蕊,2-三氟甲基噁唑类衍生物的合成方法, 中国,201110120698.7。
杜云飞,刘乐,贺巧巧,赵康,1,3-二腈基2-取代-1H-茚类衍生物及其制备方 法,中国,201210044059.1。
杜云飞,吕晶磊,尚巳耘,赵康,一种四氢-γ-咔啉类衍生物的合成方法,中 国,201310022038.4。
杜云飞,李旭明,张翔,赵康,一种二苯西平类衍生物的合成方法,中国,2013 10455049.1。
杜云飞,吕晶磊,赵康,一种2-吲哚酮-3-羧酸酯类衍生物的合成方法,中国,2 01310503250.2。
杜云飞,尚巳耘,赵康,一种合成二苯并二氢-1,3-二氮杂䓬类衍生物的方法, 中国,201310608894.8。
杜云飞,程然,赵康,一种通过环合消除一锅法合成4(3H)-喹唑啉酮衍生物的 方法,中国,201410113565.0。
杜云飞,程然,赵康,一种通过环合消除一锅法合成4(3H)-喹唑啉酮衍生物的 方法,中国,201410113565.0。
杜云飞,袁玉成,赵康,一种通过C–N氧化偶联合成取代二氨基烯烃衍生物的方 法,中国,2014104793464
Highlighted Publications
Shang, S.; Zhang-Negrerie, D.; Du, Y.; Zhao, K. Intramolecular Metal-free Oxidative Aryl-aryl Coupling: An Unusual Hypervalent Iodine-mediated Rearrangement of 2-Substituted N-Phenylbenzamides. Angew. Chem., Int. Ed. 2014, 53, 6216 (Hot Paper).
Liu, L.; Lu, H.; Wang, H.; Yang, C.; Zhang, X.; Zhang-Negrerie, D.; Du, Y.; Zhao, K. PhI(OCOCF3)2-Mediated C-C Bond Formation Concomitant with a 1,2-Aryl Shift in a Metal-Free Synthesis of 3-Arylquinolin-2-ones. Org. Lett. 2013, 15, 2906.
Du, Y.-F.; Liu, R.-H.; Linn, G.; Zhao, K. Synthesis of N-Substituted Indole Derivatives via PIFA-Mediated Intramolecular Cyclization. Org. Lett. 2006, 8, 5919.
Landry, D. W.; Zhao, K.; Yang, G. X. Q.; Glickman, M; Georgiadis, T. M. Antibody-Catalyzed Degradation of Cocaine. Science 1993, 259, 1899.
Stork, G.; Zhao, K. Total Synthesis of (-)-Histrionicotoxin and (-)-Histrionicotoxin 235A. J. Am. Chem. Soc. 1990, 112, 5875.
ResearcherID Publications
Year Title Author(s) Source Volume
2006 Synthesis of N-substituted indole derivatives via PIFA-mediated intramolecular cyclization Du, Yunfei; Liu, Renhe; Linn, Gregory; et al. Organic Letters 8
2005 5,6-dimethoxy-1-(4-tolylsulfonyl)benzo[c]isoxazol-3(1H)-one Shang, ZH; Zhao, K Acta Crystallographica Section E-Structure Reports Online 61
2006 One facile preparation of N-aroyl-N '-arylsulfonylhydrazines by oxidation of aromatic aldehyde N-arylsulfonylhydrazones with bis(trifluoroacetoxy)iodobenzene Shang, ZH; Reiner, J; Zhao, K Synthetic Communications 36
2006 Determination of risedronate in rat plasma samples by ion-pair high-performance liquid chromatography with UV detector Jia, HJ; Li, W; Zhao, K Analytica Chimica Acta 562
2006 Determination of omeprazole in rat plasma by high-performance liquid chromatography without solvent extraction Jia, HJ; Li, W; Zhao, K Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 837
2006 A new application of the Pictet-Spengler reaction to the preparation of 4-substituted 1H-2,3-benzoxazines Zheng, Xiufang; Wang, Xiaolei; Chang, Junbiao; et al. Synlett
2007 Virtual screening for finding natural inhibitor against cathepsin-L for SARS therapy Wang, S.-Q.; Du, Q.-S.; Zhao, K.; et al. Amino Acids 33
2007 Synthesis of 1,3-disubstituted N-amino-1,2,3,4-tetrahydroisoquinolines Zhang, Li; Zheng, Xiu-Fang; Linn, Gregory; et al. Synlett
2007 Determination of clarithromycin in rat plasma by HPLC-UV method with pre-column derivatization Li, Wei; Ha, Huijuan; Zhao, Kang Talanta 71
2008 Synthesis of functionalized enamines: A facile and efficient protocol toward N-protected alpha,beta-dehydroamino acid derivatives Sun, Yun; Wang, Xiaozhao; Zheng, Xiufang; et al. Synlett