Home / People / Faculty / Qingzhi Gao

Qingzhi Gao——Professor

Nationality:
CHINA
Phone:
022-27892050
Email:
qingzhi@tju.edu.cn
Office:
Room A609, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1994 Ph. D. Nagoya University, JP
1994-1999 Postdoctoral Stanford University, USA
Professional Experience
1994-2001 Research Scientist Tokyo, JAPAN
1999-2000 Postdoctoral fellow Stanford University, California, USA
2001-2009 Senior Research Scientist XenoPort, Inc. California, USA
2009-2015 Professor Tianjin University, Tianjin, CHINA
2010-2015 Director Tianjin Key Laboratory
Research Area

The research of the Gao group covers medicinal chemistry and molecular targeting, synthetic chemistry and organo catalysis, and computer-aided drug design, aimed at the discovery of functional drug delivery carriers and understanding mechanisms of molecular targeting. Specific areas include a) strategies for development of small molecular anti-cancer drugs for targeted therapy, b) design and development of actively transportable small molecule drugs or protein-drug conjugates, c) discovery and development of novel drug-delivery carriers and pharmaceutics based on supramolecular chemistry, d) computer aided molecular design and modeling for innovative drug discovery and mechanistic study of drug transporters.

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Honors and Awards
Patents
Highlighted Publications
Qian Mi, Yuru Ma, Ran Liu, Xiangqian Gao, Pengxing Liu, Yi Mi, Xuegang Fu, and QingzhiGao*, 2-Deoxyglucose Conjugated Platinum (II) Complexes for Targeted Therapy: Design, Synthesis, and Antitumor Activity. Journal of Biomolecular Structure & Dynamics, 2015, 30,1-12.
Hong Li, Xiangqian Gao, Ran Liu, Yu Wang, Menghua Zhang, Zheng Fu, Yi Mi, Yiqiang Wang, Zhi Yao, Qingzhi Gao*, Glucose conjugated platinum(II) complex: Antitumor superiority to oxaliplatin, combination effect and mechanism of action. European Journal of Medicinal Chemistry, 2015, 101, 400-408.
Liu, P.; Lu, Y.; Li, H.; Gao, X.; Liu, R.; Zhang-Negrerie, D.; Shi, Y.; Wang, Y.; Wang, S.; Gao, Q. Highly Water-soluble Platinum(II) Complex as GLUT Substrate for Targeted Therapy: Improved Anticancer Efficacy and Ttransporter-mediated Cytotoxic Properties. Chem. Commun. 2013, 49, 2421.
Lu, Y.; Gao, X.; Wu, M.; Zhang-Negrerie, D.; Gao, Q. Strategies on the Development of Small Molecule Anticancer Drugs for Targeted Therapy. Mini-Rev in Med. Chem. 2011, 11, 611.
Qingzhi Gao, Q.; Yang, L.; Zhu, Y. Pharmacophore Based Drug Design Approach as a Practical Process in Drug Discovery Current. Comput-Aided Drug Design 2010, 6, 37.
Ye, Y.; Wei, J.; Dai, X.; Gao, Q. Computational Studies of the Binding Modes of A2A Adenosine Receptor Antagonists. Amino Acids 2008, 35, 389.
Wei, J.; Wang, S.; Gao, S.; Dai X.; Qingzhi Gao, Q. 3D-Pharmacophore Models for Selective A2A and A2B Adenosine Receptor Antagonists. J. Chem. Inf. Model 2007, 47, 613.
ResearcherID Publications
Year Title Author(s) Source Volume
2008 [Advances in the study of A2B adenosine receptor antagonists]. Wei, Jing; Yu, Wen-Quan; Gao, Qing-Zhi Yao xue xue bao = Acta pharmaceutica Sinica 43
2007 3D-pharmacophore models for selective A(2A) and A(2B) adenosine receptor antagonists Wei, Jing; Wang, Songqing; Gao, Shaofen; et al. Journal of Chemical Information and Modeling 47
2008 Computational studies of the binding modes of A(2A) adenosine receptor antagonists Ye, Y.; Wei, J.; Dai, X.; et al. Amino Acids 35
2009 Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship (SAR) Discussion of Dipeptidyl Boronate Proteasome Inhibitors, Part I: Comprehensive Understanding of the SAR of alpha-Amino Acid Boronates Zhu, Yongqiang; Zhao, Xin; Zhu, Xinrong; et al. Journal of Medicinal Chemistry 52
2009 Molecular docking study of A(3) adenosine receptor antagonists and pharmacophore-based drug design Wei, Jing; Li, Hui; Qu, Wanlu; et al. Neurochemistry International 55
2009 A three-dimensional pharmacophore model for RXR alpha agonists Dong, Aiguo; Huo, Junfeng; Gao, Qingzhi; et al. Journal of Molecular Structure 920
2009 3D-pharmacophore model for RXR gamma agonists Dong, Aiguo; Wei, Jing; Gao, Qingzhi Neurochemistry International 54
2010 Pharmacophore Based Drug Design Approach as a Practical Process in Drug Discovery Gao, Qingzhi; Yang, Lulu; Zhu, Yongqiang Current Computer-Aided Drug Design 6
2010 3D-QSAR study of corticotropin-releasing factor 1 antagonists and pharmacophore-based drug design Ye, Yingda; Liao, Qinghua; Wei, Jing; et al. Neurochemistry International 56
2010 3D Pharmacophore Based Virtual Screening of A(2A) Adenosine Receptor Antagonists Wei, Jing; Qu, Wanlu; Ye, Yingda; et al. Protein and Peptide Letters 17
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