Home / People / Faculty / Qingzhi Gao

Qingzhi Gao——Professor

Nationality:
CHINA
Phone:
022-27892050
Email:
qingzhi@tju.edu.cn
Office:
Room A609, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1994 Ph. D. Nagoya University, JP
1994-1999 Postdoctoral Stanford University, USA
Professional Experience
1994-2001 Research Scientist Tokyo, JAPAN
1999-2000 Postdoctoral fellow Stanford University, California, USA
2001-2009 Senior Research Scientist XenoPort, Inc. California, USA
2009-2015 Professor Tianjin University, Tianjin, CHINA
2010-2015 Director Tianjin Key Laboratory
Research Area

The research of the Gao group covers medicinal chemistry and molecular targeting, synthetic chemistry and organo catalysis, and computer-aided drug design, aimed at the discovery of functional drug delivery carriers and understanding mechanisms of molecular targeting. Specific areas include a) strategies for development of small molecular anti-cancer drugs for targeted therapy, b) design and development of actively transportable small molecule drugs or protein-drug conjugates, c) discovery and development of novel drug-delivery carriers and pharmaceutics based on supramolecular chemistry, d) computer aided molecular design and modeling for innovative drug discovery and mechanistic study of drug transporters.

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Honors and Awards
Patents
Highlighted Publications
Qian Mi, Yuru Ma, Ran Liu, Xiangqian Gao, Pengxing Liu, Yi Mi, Xuegang Fu, and QingzhiGao*, 2-Deoxyglucose Conjugated Platinum (II) Complexes for Targeted Therapy: Design, Synthesis, and Antitumor Activity. Journal of Biomolecular Structure & Dynamics, 2015, 30,1-12.
Hong Li, Xiangqian Gao, Ran Liu, Yu Wang, Menghua Zhang, Zheng Fu, Yi Mi, Yiqiang Wang, Zhi Yao, Qingzhi Gao*, Glucose conjugated platinum(II) complex: Antitumor superiority to oxaliplatin, combination effect and mechanism of action. European Journal of Medicinal Chemistry, 2015, 101, 400-408.
Liu, P.; Lu, Y.; Li, H.; Gao, X.; Liu, R.; Zhang-Negrerie, D.; Shi, Y.; Wang, Y.; Wang, S.; Gao, Q. Highly Water-soluble Platinum(II) Complex as GLUT Substrate for Targeted Therapy: Improved Anticancer Efficacy and Ttransporter-mediated Cytotoxic Properties. Chem. Commun. 2013, 49, 2421.
Lu, Y.; Gao, X.; Wu, M.; Zhang-Negrerie, D.; Gao, Q. Strategies on the Development of Small Molecule Anticancer Drugs for Targeted Therapy. Mini-Rev in Med. Chem. 2011, 11, 611.
Qingzhi Gao, Q.; Yang, L.; Zhu, Y. Pharmacophore Based Drug Design Approach as a Practical Process in Drug Discovery Current. Comput-Aided Drug Design 2010, 6, 37.
Ye, Y.; Wei, J.; Dai, X.; Gao, Q. Computational Studies of the Binding Modes of A2A Adenosine Receptor Antagonists. Amino Acids 2008, 35, 389.
Wei, J.; Wang, S.; Gao, S.; Dai X.; Qingzhi Gao, Q. 3D-Pharmacophore Models for Selective A2A and A2B Adenosine Receptor Antagonists. J. Chem. Inf. Model 2007, 47, 613.
ResearcherID Publications
Year Title Author(s) Source Volume
2012 Computer-aided de novo ligand design and docking/molecular dynamics study of Vitamin D receptor agonists Shen, Xiu-Long; Takimoto-Kamimura, Midori; Wei, Jing; et al. Journal of Molecular Modeling 18
2013 The discovery of a facile access to the synthesis of NSAID dendritic prodrugs Du, Zuyin; Lu, Yanhui; Dai, Xuedong; et al. Journal of Chemical Research
2013 Synthesis of NO-NSAID dendritic prodrugs via Passerini reaction: new approach to the design of dendrimer-drug conjugates Du, Zuyin; Lu, Yanhui; Dai, Xuedong; et al. Journal of Chemical Research
2013 Highly water-soluble platinum(II) complexes as GLUT substrates for targeted therapy: improved anticancer efficacy and transporter-mediated cytotoxic properties Liu, Pengxing; Lu, Yanhui; Gao, Xiangqian; et al. Chemical Communications 49
2015 Glucose conjugated platinum(II) complex: Antitumor superiority to oxaliplatin, combination effect and mechanism of action. Li, Hong; Gao, Xiangqian; Liu, Ran; et al. European journal of medicinal chemistry 101
2015 2-Deoxyglucose conjugated platinum (II) complexes for targeted therapy: design, synthesis, and antitumor activity Mi, Q.; Ma, Y.; Gao, X.; et al. J Biomol Struct Dyn 30
2016 Mechanistic Study of Human Glucose Transport Mediated by GLUT1 Fu, X.; Zhang, G.; Liu, R.; et al. J Chem Inf Model
2016 Galactose conjugated platinum(II) complex targeting the Warburg effect for treatment of non-small cell lung cancer and colon cancer. Wu, Meng; Li, Hong; Liu, Ran; et al. European journal of medicinal chemistry 110
2016 Cyanine-based 1-amino-1-deoxyglucose as fluorescent probes for glucose transporter mediated bioimaging Xu, Hu; Liu, Xinyu; Yang, Jinna; et al. Biochemical and Biophysical Research Communications
2008 [Advances in the study of A2B adenosine receptor antagonists]. Wei, Jing; Yu, Wen-Quan; Gao, Qing-Zhi Yao xue xue bao = Acta pharmaceutica Sinica 43
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