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Qingzhi Gao——Professor

Room A609, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
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Education Experience
1994 Ph. D. Nagoya University, JP
1994-1999 Postdoctoral Stanford University, USA
Professional Experience
1994-2001 Research Scientist Tokyo, JAPAN
1999-2000 Postdoctoral fellow Stanford University, California, USA
2001-2009 Senior Research Scientist XenoPort, Inc. California, USA
2009-2015 Professor Tianjin University, Tianjin, CHINA
2010-2015 Director Tianjin Key Laboratory
Research Area

The research of the Gao group covers medicinal chemistry and molecular targeting, synthetic chemistry and organo catalysis, and computer-aided drug design, aimed at the discovery of functional drug delivery carriers and understanding mechanisms of molecular targeting. Specific areas include a) strategies for development of small molecular anti-cancer drugs for targeted therapy, b) design and development of actively transportable small molecule drugs or protein-drug conjugates, c) discovery and development of novel drug-delivery carriers and pharmaceutics based on supramolecular chemistry, d) computer aided molecular design and modeling for innovative drug discovery and mechanistic study of drug transporters.


Honors and Awards
Highlighted Publications
Qian Mi, Yuru Ma, Ran Liu, Xiangqian Gao, Pengxing Liu, Yi Mi, Xuegang Fu, and QingzhiGao*, 2-Deoxyglucose Conjugated Platinum (II) Complexes for Targeted Therapy: Design, Synthesis, and Antitumor Activity. Journal of Biomolecular Structure & Dynamics, 2015, 30,1-12.
Hong Li, Xiangqian Gao, Ran Liu, Yu Wang, Menghua Zhang, Zheng Fu, Yi Mi, Yiqiang Wang, Zhi Yao, Qingzhi Gao*, Glucose conjugated platinum(II) complex: Antitumor superiority to oxaliplatin, combination effect and mechanism of action. European Journal of Medicinal Chemistry, 2015, 101, 400-408.
Liu, P.; Lu, Y.; Li, H.; Gao, X.; Liu, R.; Zhang-Negrerie, D.; Shi, Y.; Wang, Y.; Wang, S.; Gao, Q. Highly Water-soluble Platinum(II) Complex as GLUT Substrate for Targeted Therapy: Improved Anticancer Efficacy and Ttransporter-mediated Cytotoxic Properties. Chem. Commun. 2013, 49, 2421.
Lu, Y.; Gao, X.; Wu, M.; Zhang-Negrerie, D.; Gao, Q. Strategies on the Development of Small Molecule Anticancer Drugs for Targeted Therapy. Mini-Rev in Med. Chem. 2011, 11, 611.
Qingzhi Gao, Q.; Yang, L.; Zhu, Y. Pharmacophore Based Drug Design Approach as a Practical Process in Drug Discovery Current. Comput-Aided Drug Design 2010, 6, 37.
Ye, Y.; Wei, J.; Dai, X.; Gao, Q. Computational Studies of the Binding Modes of A2A Adenosine Receptor Antagonists. Amino Acids 2008, 35, 389.
Wei, J.; Wang, S.; Gao, S.; Dai X.; Qingzhi Gao, Q. 3D-Pharmacophore Models for Selective A2A and A2B Adenosine Receptor Antagonists. J. Chem. Inf. Model 2007, 47, 613.
ResearcherID Publications
Year Title Author(s) Source Volume
2012 Computer-aided de novo ligand design and docking/molecular dynamics study of Vitamin D receptor agonists Shen, Xiu-Long; Takimoto-Kamimura, Midori; Wei, Jing; et al. Journal of Molecular Modeling 18
2013 The discovery of a facile access to the synthesis of NSAID dendritic prodrugs Du, Zuyin; Lu, Yanhui; Dai, Xuedong; et al. Journal of Chemical Research
2013 Synthesis of NO-NSAID dendritic prodrugs via Passerini reaction: new approach to the design of dendrimer-drug conjugates Du, Zuyin; Lu, Yanhui; Dai, Xuedong; et al. Journal of Chemical Research
2013 Highly water-soluble platinum(II) complexes as GLUT substrates for targeted therapy: improved anticancer efficacy and transporter-mediated cytotoxic properties Liu, Pengxing; Lu, Yanhui; Gao, Xiangqian; et al. Chemical Communications 49
2015 Glucose conjugated platinum(II) complex: Antitumor superiority to oxaliplatin, combination effect and mechanism of action. Li, Hong; Gao, Xiangqian; Liu, Ran; et al. European journal of medicinal chemistry 101
2015 2-Deoxyglucose conjugated platinum (II) complexes for targeted therapy: design, synthesis, and antitumor activity Mi, Q.; Ma, Y.; Gao, X.; et al. J Biomol Struct Dyn 30
2016 Mechanistic Study of Human Glucose Transport Mediated by GLUT1 Fu, X.; Zhang, G.; Liu, R.; et al. J Chem Inf Model
2016 Galactose conjugated platinum(II) complex targeting the Warburg effect for treatment of non-small cell lung cancer and colon cancer. Wu, Meng; Li, Hong; Liu, Ran; et al. European journal of medicinal chemistry 110
2016 Cyanine-based 1-amino-1-deoxyglucose as fluorescent probes for glucose transporter mediated bioimaging Xu, Hu; Liu, Xinyu; Yang, Jinna; et al. Biochemical and Biophysical Research Communications
2008 [Advances in the study of A2B adenosine receptor antagonists]. Wei, Jing; Yu, Wen-Quan; Gao, Qing-Zhi Yao xue xue bao = Acta pharmaceutica Sinica 43
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