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Jay Siegel——Professor

Room A203, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
Group weblink
Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
2018 1,2,3-versus 1,2-Indeno Ring Fusions Influence Structure Property and Chirality of Corannulene Bowls Liu, Shi; Roch, Loiec M.; Allemann, Oliver; et al. Journal of Organic Chemistry 83
2018 Chiral Atropisomeric Indenocorannulene Bowls: Critique of the Cahn-Ingold-Prelog Conception of Molecular Chirality. Wang, Yujia; Allemann, Oliver; Balaban, T Silviu; et al. Angewandte Chemie (International ed. in English)
2018 Kurt M. Mislow (1923-2017) Pioneer of Modern Stereochemistry Siegel, Jay S. Angewandte Chemie-International Edition 57
2018 Pauli Repulsion Versus van der Waals: Interaction of Indenocorannulene with a Cu(111) Surface Zoppi, Laura; Stockl, Quinn; Mairena, Anais; et al. Journal of Physical Chemistry B 122
2017 Allotropy by design-Carbon nanohoops Siegel, Jay S. Science 356
2017 Decakis(arylthio)corannulenes: Transferable Photochemical and Redox Parameters and Photovoltaic Device Performance Deng, Yanan; Xu, Bokai; Castro, Edison; et al. European Journal of Organic Chemistry
2017 Diindenocorannulenes: Curved Aromatics Blending Bowl-in-Bowl Assembly and Nanocarbon Material Properties Tian, Xiaoqi; Roch, Loic M.; Baldridge, Kim K.; et al. European Journal of Organic Chemistry
2017 Indenocorannulene-Based Materials: Effect of Solid-State Packing and Intermolecular Interactions on Optoelectronic Properties Roch, Loic M.; Zoppi, Laura; Siegel, Jay S.; et al. Journal of Physical Chemistry C 121
2017 Trifluoromethyl/Perfluoroalkyl Corannulenes: Directed Synthesis and Photophysical Characterization Xia, Yeqing; Guo, TianJian; Baldridge, Kim K.; et al. European Journal of Organic Chemistry
2016 Conformations of large macrocycles and ring-in-ring complexes Klosterman, Jeremy K.; Veliks, Janis; Frantz, Derik K.; et al. Organic Chemistry Frontiers 3