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Jay Siegel——Professor

Nationality:
USA
Phone:
022-87402050
Email:
dean_spst@tju.edu.cn
Office:
Room A203, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Patents
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
1996 Enantioselective synthesis of copper(I) bipyridine based helicates by chiral templating of secondary structure: Transmission of stereochemistry on the nanometer scale Woods, C. R.; Benaglia, M.; Cozzi, F.; et al. Angewandte Chemie-International Edition in English 35
1996 Structure and dynamics of the Cr(CO)(3) complexes of triquinacene and dimethylenecyclobutene by Hartree-Fock and density functional methods Baldridge, K. K.; Siegel, J. S. Journal of Physical Chemistry 100
1996 Supramolecular chemistry. Concepts and perspectives - Lehn,JM Siegel, J. S. Science 271
1996 Synthesis and characterization of the first corannulene cyclophane Seiders, T. J.; Baldridge, K. K.; Siegel, J. S. Journal of the American Chemical Society 118
1995 CHIRALLY ENSHROUDED 2,6-DIARYLBENZOIC ACIDS WITH 2-FOLD SYMMETRY Chen, C. T.; Chadha, R.; Siegel, J. S.; et al. Tetrahedron Letters 36
1995 FROM BOWLS TO SADDLES Siegel, J. S.; Seiders, T. J. Chemistry in Britain 31
1995 INTERACTION BETWEEN STACKED ARYL GROUPS IN 1,8-DIARYLNAPHTHALENES - DOMINANCE OF POLAR/PI OVER CHARGE-TRANSFER EFFECTS Cozzi, F.; Siegel, J. S. Pure and Applied Chemistry 67
1995 LONE C-C SINGLE BONDS IN ANTHRACENE DIMERS - THE STRUCTURE OF BI(ANTHRACENE-9,10-DIMETHYLENE) PHOTODIMER IS REDETERMINED Battersby, T. R.; Gantzel, P.; Baldridge, K. K.; et al. Tetrahedron Letters 36
1995 PARTIAL BOND LOCALIZATION IN THE CRYSTAL-STRUCTURE OF TRISBICYCLO 2.2.1 HEPTABENZENE AND ITS EFFECT ON CR-ARENE DYNAMICS Frank, N. L.; Baldridge, K. K.; Gantzel, P.; et al. Tetrahedron Letters 36
1995 POLAR INTERACTIONS BETWEEN STACKED PI-SYSTEMS IN FLUORINATED 1,8-DIARYLNAPHTHALENES - IMPORTANCE OF QUADRUPOLE-MOMENTS IN MOLECULAR RECOGNITION Cozzi, F.; Ponzini, F.; Annunziata, R.; et al. Angewandte Chemie-International Edition in English 34