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Jay Siegel——Professor

Nationality:
USA
Phone:
022-87402050
Email:
dean_spst@tju.edu.cn
Office:
Room A203, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Patents
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
1995 SIMPLE ONE-STEP SYNTHESIS OF 3-BROMO-1,10-PHENANTHROLINE AND 3,8-DIBROMO-1,10-PHENANTHROLINE - FUNDAMENTAL BUILDING-BLOCKS IN THE DESIGN OF METAL-CHELATES Tzalis, D.; Tor, Y.; Failla, S.; et al. Tetrahedron Letters 36
1995 SYNTHESIS AND CHARACTERIZATION OF TRISBICYCLO 2.1.1 HEXABENZENE, A HIGHLY STRAINED BICYCLOANNELATED BENZENE Frank, N. L.; Baldridge, K. K.; Siegel, J. S. Journal of the American Chemical Society 117
1995 SYNTHESIS AND CONFORMATIONAL-ANALYSIS OF TRIOXATRICORNAN-BASED MACROCYCLOPHANES Lofthagen, M.; Siegel, J. S. Journal of Organic Chemistry 60
1995 Synthesis and structure of the nanodimensional multicyclophane ’’Kuratowski cyclophane’’, an achiral molecule with nonplanar K-3,K-3 topology Chen, C. T.; Gantzel, P.; Siegel, J. S.; et al. Angewandte Chemie-International Edition 34
1995 SYNTHESIS OF METALLOMACROCYCLOPHANES - DEDUCTION OF STRUCTURE FROM ELECTROSPRAY-IONIZATION MASS-SPECTROSCOPY AND MOLECULAR MECHANICS COMPUTATIONS Lofthagen, M.; Siegel, J. S.; Hackett, M. Tetrahedron 51
1995 THE CENTRAL BOND-LENGTH IN 1,2-DIARYLETHANES Kahr, B.; Mitchell, C. A.; Chance, J. M.; et al. Journal of the American Chemical Society 117
1995 THE CRYSTAL-STRUCTURE OF A HEPTIPTYCENE-CHLOROBENZENE CLATHRATE Venugopalan, P.; Burgi, H. B.; Frank, N. L.; et al. Tetrahedron Letters 36
1995 X-RAY-DIFFRACTION EVIDENCE FOR A CYCLOHEXATRIENE MOTIF IN THE MOLECULAR-STRUCTURE OF TRIS(BICYCLO 2.1.1 HEXENO)BENZENE - BOND ALTERNATION AFTER THE REFUTATION OF THE MILLS-NIXON THEORY Burgi, H. B.; Baldridge, K. K.; Hardcastle, K.; et al. Angewandte Chemie-International Edition in English 34
1994 MILLS-NIXON EFFECT - WHEREFORE ART THOU Siegel, J. S. Angewandte Chemie-International Edition in English 33
1994 THROUGH-SPACE POLAR-PI EFFECTS ON THE ACIDITY AND HYDROGEN-BONDING CAPACITY OF CARBOXYLIC-ACIDS Chen, C. T.; Siegel, J. S. Journal of the American Chemical Society 116