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Jay Siegel——Professor

Nationality:
USA
Phone:
022-87402050
Email:
dean_spst@tju.edu.cn
Office:
Room A203, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Patents
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
1994 UNUSUAL PHOTOLUMINESCENCE BEHAVIOR OF C-70 Argentine, S. M.; Francis, A. H.; Chen, C. C.; et al. Journal of Physical Chemistry 98
1993 1,6,7,10-TETRAMETHYLFLUORANTHENE - SYNTHESIS AND STRUCTURE OF A TWISTED POLYNUCLEAR AROMATIC HYDROCARBON Borchardt, A.; Hardcastle, K.; Gantzel, P.; et al. Tetrahedron Letters 34
1993 BALANCING STERIC AND ELECTRONIC FACTORS IN PUSH-PULL BENZENES - AN AB-INITIO STUDY ON THE MOLECULAR-STRUCTURE OF 1,3,5-TRIAMINO-2,4,6-TRINITROBENZENE AND RELATED-COMPOUNDS Baldridge, K. K.; Siegel, J. S. Journal of the American Chemical Society 115
1993 DOMINANCE OF POLAR/PI OVER CHARGE-TRANSFER EFFECTS IN STACKED PHENYL INTERACTIONS Cozzi, F.; Cinquini, M.; Annuziata, R.; et al. Journal of the American Chemical Society 115
1993 METAL-BINDING BY THE TRISOXAZOLE PORTION OF THE MARINE NATURAL PRODUCT DIHYDROHALICHONDRAMIDE James, D. M.; Wintner, E.; Faulkner, D. J.; et al. Heterocycles 35
1993 MOLECULAR DESIGN, CHEMICAL SYNTHESIS, KINETIC-STUDIES, CALCULATIONS, AND BIOLOGICAL STUDIES OF NOVEL ENEDIYNES EQUIPPED WITH TRIGGERING, DETECTION, AND DEACTIVATING DEVICES - MODEL DYNEMICIN-A EPOXIDE AND CIS-DIOL SYSTEMS Nicolaou, K. C.; Dai, W. M.; Hong, Y. P.; et al. Journal of the American Chemical Society 115
1993 SYNTHESIS, STRUCTURE, AND DYNAMICS OF ENDO-(STARPHENYLENE)CHROMIUM TRICARBONYL DERIVATIVES - OBSERVATION OF METAL ARENE MIGRATION AND HINDERED METAL-TRIPOD ROTATION Nambu, M.; Mohler, D. L.; Hardcastle, K.; et al. Journal of the American Chemical Society 115
1992 BOND ALTERNATION IN TRIANNELATED BENZENES - DISSECTION OF CYCLIC PI FROM MILLS NIXON EFFECTS Baldridge, K. K.; Siegel, J. S. Journal of the American Chemical Society 114
1992 CRYPTOCLASTIC DIASTEREOTOPISM - NMR EVIDENCE FOR THE CHIROTOPICITY OF THE METHYL-GROUP IN (ALPHA-DEUTERIO-ORTHO-CHLOROTOLUENE)CHROMIUM TRICARBONYL Restelli, A.; Siegel, J. S. Journal of the American Chemical Society 114
1992 EFFECT OF TRANSITION-METAL COMPLEXATION ON THE STEREODYNAMICS OF PERSUBSTITUTED ARENES - EVIDENCE FOR STERIC COMPLEMENTARITY BETWEEN ARENE AND METAL TRIPOD Kilway, K. V.; Siegel, J. S. Journal of the American Chemical Society 114