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Jay Siegel——Professor

Nationality:
USA
Phone:
022-87402050
Email:
dean_spst@tju.edu.cn
Office:
Room A203, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Patents
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
1992 EXPERIMENTAL-OBSERVATION OF THE BARRIER TO ROTATION AROUND THE METAL ARENE BOND IN 1,4-BIS(4,4-DIMETHYL-3-OXOPENTYL)-2,3,5,6-TETRAETHYLBENZENE MOLYBDENUM TRICARBONYL Kilway, K. V.; Siegel, J. S. Organometallics 11
1992 LEFT-HANDED COMMENTS Siegel, J. S. Science 258
1992 POLAR/PI INTERACTIONS BETWEEN STACKED ARYLS IN 1,8-DIARYLNAPHTHALENES Cozzi, F.; Cinquini, M.; Annunziata, R.; et al. Journal of the American Chemical Society 114
1992 STRUCTURE OF CENTRALLY BOUND ANGULAR-(TERPHENYLENE)CHROMIUM TRICARBONYL Nambu, M.; Hardcastle, K.; Baldridge, K. K.; et al. Journal of the American Chemical Society 114
1992 SYNTHESIS AND DYNAMICS OF THE CORANNULENE NUCLEUS Borchardt, A.; Fuchicello, A.; Kilway, K. V.; et al. Journal of the American Chemical Society 114
1992 SYNTHESIS OF TRIOXATRICORNAN AND DERIVATIVES - USEFUL KEYSTONES FOR THE CONSTRUCTION OF RIGID MOLECULAR CAVITIES Lofthagen, M.; Vernonclark, R.; Baldridge, K. K.; et al. Journal of Organic Chemistry 57
1991 EVIDENCE FOR GATED STEREODYNAMICS IN 1,4-BIS(4,4-DIMETHYL-3-OXOPENTYL)-2,3,5,6-TETRAETHYLBENZENE CHROMIUM TRICARBONYL Kilway, K. V.; Siegel, J. S. Journal of the American Chemical Society 113
1991 SYNTHESIS OF UNSUBSTITUTED AND 4,4’-SUBSTITUTED OLIGOBIPYRIDINES AS LIGAND STRANDS FOR HELICATE SELF-ASSEMBLY Harding, M. M.; Koert, U.; Lehn, J. M.; et al. Helvetica Chimica Acta 74
1991 SYNTHESIS, STRUCTURE, AND DYNAMICS OF A MACROCYCLOPHANE Lofthagen, M.; Chadha, R.; Siegel, J. S. Journal of the American Chemical Society 113
1991 TORSIONAL ANGLE AND CONFORMATION IN 2-VINYLANTHRACENE STUDIED BY NMR-SPECTROSCOPY AND MO CALCULATIONS Ni, Y.; Siegel, J. S.; Hsu, V. L.; et al. Journal of Physical Chemistry 95