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Jay Siegel——Professor

Nationality:
USA
Phone:
022-87402050
Email:
dean_spst@tju.edu.cn
Office:
Room A203, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Patents
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
1991 TORSIONAL ANGLES IN ALKENYLARENES STUDIED BY SEMIEMPIRICAL MOLECULAR-ORBITAL METHODS Ni, Y.; Siegel, J. S.; Kearns, D. R. Journal of Physical Chemistry 95
1990 2ND-HARMONIC GENERATION FROM NONDIPOLAR NONCENTROSYMMETRIC AROMATIC CHARGE-TRANSFER MOLECULES Ledoux, I.; Zyss, J.; Siegel, J. S.; et al. Chemical Physics Letters 172
1989 DRAMATIC STERIC DISTORTIONS AND ELECTRONIC DEMANDS IN 1,3,5-TRIS(DIALKYLAMINO)-2,4,6-TRINITROBENZENE - STUDY OF A SEVERELY WARPED BENZENE Chance, J. M.; Kahr, B.; Buda, A. B.; et al. Journal of the American Chemical Society 111
1989 STRUCTURE AND REACTIVITY OF ILLUDINS McMorris, T. C.; Kelner, M. J.; Chadha, R. K.; et al. Tetrahedron 45
1988 AN INDUCED BARRIER TO ROTATION ABOUT THE ETA-6-ARENE METAL BOND IN CENTRALLY BOUND BENT-TERPHENYLENECHROMIUM TRICARBONYL - A GAUGE FOR AROMATIC CHARACTER AND BOND LOCALIZATION Nambu, M.; Siegel, J. S. Journal of the American Chemical Society 110
1988 DICHLOROFLUOROMETHANE-D - A VERSATILE SOLVENT FOR VT-NMR EXPERIMENTS Siegel, J. S.; Anet, F. A. L. Journal of Organic Chemistry 53
1987 CONFORMATIONAL CYCLOENANTIOMERISM IN 1,2-BIS(1-BROMOETHYL)-3,4,5,6-TETRAISOPROPYLBENZENE Singh, M. D.; Siegel, J.; Biali, S. E.; et al. Journal of the American Chemical Society 109
1987 SPONTANEOUS ASSEMBLY OF DOUBLE-STRANDED HELICATES FROM OLIGOBIPYRIDINE LIGANDS AND COPPER(I) CATIONS - STRUCTURE OF AN INORGANIC DOUBLE HELIX Lehn, J. M.; Rigault, A.; Siegel, J.; et al. Proceedings of the National Academy of Sciences of the United States of America 84
1986 STATIC AND DYNAMIC STEREOCHEMISTRY OF HEXAISOPROPYLBENZENE - A GEAR-MESHED HYDROCARBON OF EXCEPTIONAL RIGIDITY Siegel, J.; Gutierrez, A.; Schweizer, W. B.; et al. Journal of the American Chemical Society 108
1985 CONFORMATIONS AND INTERNAL MOBILITY OF SIDE-CHAINS IN HETEROSUBSTITUTED HEXAALKYLBENZENES - ISOPROPYL ETHYL AND ISOPROPYL CYCLOPROPYL SYSTEMS Weissensteiner, W.; Gutierrez, A.; Radcliffe, M. D.; et al. Journal of Organic Chemistry 50