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Jay Siegel——Professor

Nationality:
USA
Phone:
022-87402050
Email:
dean_spst@tju.edu.cn
Office:
Room A203, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Patents
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
1985 SYNTHESIS OF SEC-ALKYLACETYLENES - REDUCTION OF COBALT CARBONYL-COMPLEXES OF ACETYLENIC ALCOHOLS Nicholas, K. M.; Siegel, J. Journal of the American Chemical Society 107
1984 STEREOCHEMISTRY MISLOW, K; SIEGEL, J Science 226
1984 STEREOISOMERISM AND LOCAL CHIRALITY Mislow, K.; Siegel, J. Journal of the American Chemical Society 106
1983 EXPERIMENTAL-EVIDENCE FOR A HIGH BARRIER TO INTERNAL-ROTATION IN HEXAISOPROPYLBENZENE Siegel, J.; Mislow, K. Journal of the American Chemical Society 105
1983 LA-COUPE-DU-ROI AND ITS RELEVANCE TO STEREOCHEMISTRY - COMBINATION OF 2 HOMOCHIRAL MOLECULES TO GIVE AN ACHIRAL PRODUCT Anet, F. A. L.; Miura, S. S.; Siegel, J.; et al. Journal of the American Chemical Society 105
1981 SYNTHESIS, STRUCTURE, AND LIGAND DYNAMICS OF THE ORGANO-METALLIC ANION RU3(CO)9C2-T-BU Barnerthorsen, C.; Hardcastle, K. I.; Rosenberg, E.; et al. Inorganic Chemistry 20
Nanocomposite material for use in serial block-face scanning electron microscopy technique for immobilization of tissue samples, comprises base component containing curable resin, curing agent or hardener and monomers of carbon ELLISMAN M H; JOHNSON D; DEERNICK T J; et al.
New lipidic compound selected from amines such as (N-oleoyl-L-serine methyl ester), cyclopropyl compounds, azobenzenes, and guanidinium compounds, used as additive in lipidic cubic phase material for controlled release of e.g. DNA compounds LANDAU E M; SIEGEL J S