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Jay Siegel——Professor

Nationality:
USA
Phone:
022-87402050
Email:
dean_spst@tju.edu.cn
Office:
Room A203, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Patents
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
2015 Molecular compression chambers: exceeding the Euler modulus Baldridge, Kim K.; Siegel, Jay S. Journal of Physical Organic Chemistry 28
2015 Phase Behavior of a Designed Cyclopropyl Analogue of Monoolein: Implications for Low-Temperature Membrane Protein Crystallization Manni, Livia Salvati; Zabara, Alexandru; Osornio, Yazmin M.; et al. Angewandte Chemie-International Edition 54
2015 Stereospecific Oxidative Demetallation of Highly Functionalized CpCo(1,3-Diene) Complexes: An Experimental and Computational Study Holland, Ryan L.; O’Connor, Joseph M.; Bunker, Kevin D.; et al. Synlett 26
2015 Structure and dynamics in unsymmetrically substituted five-coordinate iridacyclopentadiene complexes Baldridge, Kim K.; Siegel, Jay S.; O’Connor, Joseph M. Journal of Physical Organic Chemistry 28
2015 Synthesis and characterization of phosphorescent platinum and iridium complexes with cyclometalated corannulene Facendola, John W.; Seifrid, Martin; Siegel, Jay; et al. Dalton Transactions 44
2015 Thiophene-fused bowl-shaped polycyclic aromatics with a dibenzo[a,g] corannulene core for organic field-effect transistors Lu, Ru-Qiang; Zhou, Yi-Nyu; Yan, Xiao-Yun; et al. Chemical Communications 51
2014 Close covalent contacts: gauging molecular compression in a molecular compression chamber Berstis, Laura; Siegel, Jay S.; Baldridge, Kim K. Physical Chemistry Chemical Physics 16
2014 CONTROLLED OXYGEN RELEASE FROM PYRIDONE ENDOPEROXIDES FOR UROLOGIC TISSUE ENGINEERING APPLICATIONS Benz, Sebastian; Noetzli, Sarah; Siegel, Jay S.; et al. Journal of Urology 191
2014 Corannulene derivatives as non-fullerene acceptors in solution-processed bulk heterojunction solar cells Lu, Ru-Qiang; Zheng, Yu-Qing; Zhou, Yi-Nyu; et al. Journal of Materials Chemistry a 2
2014 Cu(I) and Ag(I) complexes of 7,10-bis-N-heterocycle-diazafluoranthenes: programmed molecular grids? Rahanyan, Nelli; Duttwyler, Simon; Linden, Anthony; et al. Dalton Transactions 43