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Jay Siegel——Professor

Nationality:
USA
Phone:
022-87402050
Email:
dean_spst@tju.edu.cn
Office:
Room A203, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Patents
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
2014 Gear-Meshed Tiling of Surfaces with Molecular Pentagonal Stars Stoeckl, Quirin; Bandera, Davide; Kaplan, Craig S.; et al. Journal of the American Chemical Society 136
2014 Induced-fit catalysis of corannulene bowl-to-bowl inversion Juricek, Michal; Strutt, Nathan L.; Barnes, Jonathan C.; et al. Nature Chemistry 6
2014 Linear bilateral extended 2,2 ’:6 ’,2 ’’-terpyridine ligands, their coordination complexes and heterometallic supramolecular networks Veliks, Janis; Tseng, Jui-Chang; Arias, Karla I.; et al. Chemical Science 5
2014 Synthesis of Bioconjugated sym-Pentasubstituted Corannulenes: Experimental and Theoretical Investigations of Supramolecular Architectures Mattarella, Martin; Berstis, Laura; Baldridge, Kim K.; et al. Bioconjugate Chemistry 25
2014 Synthesis, Structures, and Physical Properties of Aromatic Molecular-Bowl Hydrocarbons Wu, Yao-Ting; Siegel, Jay S.; Siegel, JS; et al. Polyarenes I 349
2014 Three Steps in One Pot: Synthesis of Linear Bilateral Extended 2,2 ’:6 ’,2 ’’-Terpyridineruthenium(II) Complexes Veliks, Janis; Blacque, Olivier; Siegel, Jay S. Inorganic Chemistry 53
2014 Through-space interactions in enshrouded m-terphenylsilanes Romanato, Paola; Duttwyler, Simon; Linden, Anthony; et al. Journal of Physical Organic Chemistry 27
2013 Arenium Acid Catalyzed Deuteration of Aromatic Hydrocarbons Duttwyler, Simon; Butterfield, Anna M.; Siegel, Jay S. Journal of Organic Chemistry 78
2013 Chiral Conflict among Different Helicenes Suppresses Formation of One Enantiomorph in 2D Crystallization Seibel, Johannes; Allemann, Oliver; Siegel, Jay S.; et al. Journal of the American Chemical Society 135
2013 Controlled Oxygen Release from Pyridone Endoperoxides Promotes Cell Survival under Anoxic Conditions Benz, Sebastian; Noetzli, Sarah; Siegel, Jay S.; et al. Journal of Medicinal Chemistry 56