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Jay Siegel——Professor

Room A203, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
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Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
2013 Effective Solubilization of Single-Walled Carbon Nanotubes in THF Using PEGylated Corannulene Dispersant Yilmaz, Baris; Bjorgaard, Josiah; Colbert, Christopher L.; et al. Acs Applied Materials & Interfaces 5
2013 Electron transport and optical properties of curved aromatics Zoppi, Laura; Siegel, Jay S.; Baldridge, Kim K. Wiley Interdisciplinary Reviews-Computational Molecular Science 3
2013 Five-fold symmetric penta-substituted corannulene with gelation properties and a liquid-crystalline phase Mattarella, Martin; Haberl, Johannes M.; Ruokolainen, Janne; et al. Chemical Communications 49
2013 Historical perspective on: Second-harmonic generation from non-dipolar non-centrosymmetric aromatic charge-transfer molecules [Volume 172, Issue 6, 21 September 1990, Pages 440-444] Ledoux, I.; Zyss, J.; Siegel, J. S.; et al. Chemical Physics Letters 589
2013 Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes Mattarella, Martin; Garcia-Hartjes, Jaime; Wennekes, Tom; et al. Organic & Biomolecular Chemistry 11
2013 Of Graphs and Graphenes: Molecular Design and Chemical Studies of Aromatic Compounds Baldridge, Kim K.; Siegel, Jay S. Angewandte Chemie-International Edition 52
2013 Quadruple Anionic Buckybowls by Solid-State Chemistry of Corannulene and Cesium Bauert, Tobias; Zoppi, Laura; Koller, Georg; et al. Journal of the American Chemical Society 135
2013 Second-harmonic generation from non-dipolar non-centrosymmetric aromatic charge-transfer molecules (Reprinted from Chemical Physics Letters) Ledoux, I.; Zyss, J.; Siegel, J. S.; et al. Chemical Physics Letters 589
2013 Tailored Host-Guest Lipidic Cubic Phases: A Protocell Model Exhibiting Nucleic Acid Recognition Komisarski, Marek; Osornio, Yazmin M.; Siegel, Jay S.; et al. Chemistry-a European Journal 19
2013 Tunable star-shaped triphenylamine fluorophores for fluorescence quenching detection and identification of nitro-aromatic explosives Niamnont, Nakorn; Kimpitak, Nattaporn; Wongravee, Kanet; et al. Chemical Communications 49