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Jay Siegel——Professor

Room A203, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
Group weblink
Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
2013 Wide-Ranging Host Capability of a Pd-II-Linked M2L4 Molecular Capsule with an Anthracene Shell Kishi, Norifumi; Li, Zhiou; Sei, Yoshihisa; et al. Chemistry-a European Journal 19
2012 Basicity of (2,6-Pyridino)paracyclophanes: Lone Pair-p, Cation-p, and Solvation Effects Baldridge, Kim K.; Cozzi, Franco; Siegel, Jay S. Angewandte Chemie-International Edition 51
2012 Design and Synthesis of Lipids for the Fabrication of Functional Lipidic Cubic-Phase Biomaterials Osornio, Yazmin M.; Uebelhart, Peter; Bosshard, Silvan; et al. Journal of Organic Chemistry 77
2012 Driving the Formation of Molecular Knots Siegel, Jay S. Science 338
2012 Driving the formation of molecular knots (vol 338, pg 752, 2012) Siegel, J. S.; Liang, C. Z.; Mislow, K.; et al. Science 338
2012 Immobilization of Chiral Bifunctional Organocatalysts on Poly(methylhydrosiloxane) Puglisi, Alessandra; Benaglia, Maurizio; Annunziata, Rita; et al. Chemcatchem 4
2012 Kilogram-Scale Production of Corannulene Butterfield, Anna M.; Gilomen, Bruno; Siegel, Jay S. Organic Process Research & Development 16
2012 MATERIALS CHEMISTRY Carbon origami Siegel, Jay S. Nature 486
2012 Molecular Spur Gears Comprising Triptycene Rotators and Bibenzimidazole-Based Stators Frantz, Derik K.; Linden, Anthony; Baldridge, Kim K.; et al. Journal of the American Chemical Society 134
2012 Pentagonal tiling with buckybowls: pentamethylcorannulene on Cu(111) Zoppi, Laura; Bauert, Tobias; Siegel, Jay S.; et al. Physical Chemistry Chemical Physics 14