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Jay Siegel——Professor

Room A203, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
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Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
2012 Pentagonal tiling with buckybowls: pentamethylcorannulene on Cu(111). Zoppi, Laura; Bauert, Tobias; Siegel, Jay S; et al. Physical chemistry chemical physics : PCCP 14
2012 Poly(methylhydrosiloxane)-supported chiral imidazolinones: new versatile, highly efficient and recyclable organocatalysts for stereoselective Diels-Alder cycloaddition reactions Guizzetti, Stefania; Benaglia, Maurizio; Siegel, Jay S. Chemical Communications 48
2012 Structural, Optical, and Electrochemical Properties of Three-Dimensional Push-Pull Corannulenes Wu, Yi-Lin; Stuparu, Mihaiela C.; Boudon, Corinne; et al. Journal of Organic Chemistry 77
2012 Sym-(CH2X)(5)-corannulenes: molecular pentapods displaying functional group and bioconjugate appendages Mattarella, Martin; Siegel, Jay S. Organic & Biomolecular Chemistry 10
2011 Axially Chiral Bichromophoric Fluorescent Dyes Langhals, H. Langhals H.; Hofer, A.; Bernhard, S.; et al. Journal of Organic Chemistry 76
2011 Competition between pi-Arene and Lone-Pair Halogen Coordination of Silylium Ions? Romanato, Paola; Duttwyler, Simon; Linden, Anthony; et al. Journal of the American Chemical Society 133
2011 Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes Allemann, O.; Duttwyler, S.; Romanato, P.; et al. Science 332
2011 Stereoselective Coordination of C(5)-Symmetric Corannulene Derivatives with an Enantiomerically Pure Rh(I)(nbd*) Metal Complex Bandera, D.; Baldridge, K. K.; Linden, A.; et al. Angewandte Chemie-International Edition 50
2011 Surface-assisted bowl-in-bowl stacking of nonplanar aromatic hydrocarbons Bauert, Tobias; Baldridge, Kim K.; Siegel, Jay S.; et al. Chemical Communications 47
2011 Synthesis of a D(3)-symmetric "trefoil" knotted cyclophane Arias, Karla I.; Zysman-Colman, Eli; Loren, Jon C.; et al. Chemical Communications 47