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Jay Siegel——Professor

Room A203, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
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Education Experience
1983-1985 Ph. D. Princeton University
-1985 Postdoctoral Chemistry UniversitéLouis
1980 Bachelor of Science Chemistry, Cal.St. Univ., Northridge
Professional Experience
1979-1980 014 Cal.St. Univ., Northridge
2015-2015 014 Princeton University
2015-2015 013 Université LouisPasteur
2015-2015 013 UC-SanDiego
2015-2015 012 UC-SanDiego
Research Area

The research in the group of Siegel encompasses molecular design, chemical synthesis, and structural analysis, which constitute the three principle components of modern stereochemistry. Robust transmission of structural and stereo-chemical information is fundamental to selective chemical processes such as (bio)molecular recognition, enantioselective reactions, and the assembly of designed materials. Beyond symmetry and molecular bonding, stereochemical investigations draw upon concepts from many disciplines and implement techniques such as synthetic methodology, X-ray crystallography, NMR spectroscopy, and computational theory.  Research combines synthetic and physical organic chemistry with an eye toward issues of pharmaceutical, material, and life science.

Honors and Awards
Highlighted Publications
Stöckl, Q.; Bandera, D.; Kaplan, C. S.; Ernst, K.-H.; Siegel, J. S. Gear Meshed Tiling of Surfaces with Molecular Pentagonal Stars. J. Am. Chem. Soc. 2014, 136, 606
Benz, S.; Nötzli, S.; Siegel, J. S.; Eberli, D.; Jessen, H. J. Controlled oxygen release from pyridine endoperoxides promotes cell survival under anoxic conditions. J. Med. Chem. 2013, 56, 10171.
Juríček, M.; Strutt, N. L.; Barnes, J. C.; Butterfield, A. M.; Dale, E. J.; Baldridge, K. K.; Stoddart, J. F.; Siegel, J. S. Induced-Fit Catalysis of Corannulene Bowl-to-Bowl Inversion. Nature Chem. 2013, 6, 222.
Mattarella, M.; Garcia-Hartjes, G.; Wennekes, T.; Zuilhof, H.; Siegel, J. S. Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Org. Biomol. Chem. 2013, 11, 4333.
Allemann, O.; Duttwyler, S.; Romanato, P.; Baldridge, K. K.; Siegel, J. S. Proton-Catalyzed, Silane-Fueled Friedel-Crafts Coupling of Fluoroarenes. Science 2011, 332, 574.
ResearcherID Publications
Year Title Author(s) Source Volume
2010 C-F Activation of Fluorobenzene by Silylium Carboranes: Evidence for Incipient Phenyl Cation Reactivity Duttwyler, S.; Douvris, C.; Fackler, N. L. P.; et al. Angewandte Chemie-International Edition 49
2010 Intramolecular Halogen Stabilization of Silylium Ions Directs Gearing Dynamics Romanato, P.; Duttwyler, S.; Linden, A.; et al. Journal of the American Chemical Society 132
2010 Manisyl-substituted polypyridine coordination compounds: Metallo-supramolecular networks of interdigitated double helices assembled via CH center dot center dot center dot pi and pi-pi interactions Klosterman, J. K.; Linden, A.; Frantz, D. K.; et al. Dalton Transactions 39
2010 Symmetry and polar-pi effects on the dynamics of enshrouded aryl-alkyne molecular rotors Karim, A. R.; Linden, A.; Baldridge, K. K.; et al. Chemical Science 1
2010 Synthesis, structure and properties of decakis(phenylthio)corannulene Baldridge, K. K.; Hardcastle, K. I.; Seiders, T. J.; et al. Organic & Biomolecular Chemistry 8
2009 50 Years of the Paul Karrer Gold Medal: 1959-2009 Siegel, J. S. Chimia 63
2009 Ab initio quantum chemical computations of substituent effects on triaziridine strain energy and heat of formation Peverati, R.; Siegel, J. S.; Baldridge, K. K. Physical Chemistry Chemical Physics 11
2009 Application of Structural Principles to the Design of Triptycene-Based Molecular Gears with Parallel Axes Frantz, D. K.; Baldridge, K. K.; Siegel, J. S. Chimia 63
2009 Aspects of Chemistry at UZH from Werner to the Present Day Siegel, Jay Chimia 63
2009 Building 2D Crystals from 5-Fold-Symmetric Molecules Bauert, T.; Merz, L.; Bandera, D.; et al. Journal of the American Chemical Society 131