Home / People / Faculty / Youcai Zhang

Youcai Zhang——Professor

Nationality:
CHINA
Phone:
022-87401830
Email:
youcai.zhang@tju.edu.cn
Office:
Room A506, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
2011 Ph. D. University of Kansas Medical Center, KA, USA
2011 Postdoctoral Elan Pharma, Inc., CA; 2013, Apricity, Inc. &
Professional Experience
Research Area

The research in Zhang’s group focuses on the function of transporters and nuclear receptors in pharmacology and toxicology. The major projects include: 1) preclinical development of novel transporter/receptor-targeted drugs for metabolic diseases and cancer; 2) mechanistic study of drug(herb)-induced liver and intestine injuries; 3) regulatory mechanisms of genes involved in cell death and diseases.

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Honors and Awards
Patents
Highlighted Publications
Zhang Y.; Limaye P. B.; Renaud, H. J.; Klaassen C. D. Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. Toxicol. Appl. Pharmacol. 2014, 277, 138.
Zhang Y.; Csanaky I. L.; Selwyn F. P.; Lehman-McKeema, L. D.; Klaassen C. D. Organic anion transporting polypeptide 1a4 is important for secondary bile acid metabolism. Biochem. Pharmacol. 2013, 86, 437.
Zhang Y.; Hong J. Y.; Rockwell C. E.; Copple B.; Jaeschke H.; Klaassen C. D. Effect of bile duct ligation on bile acid metabolism and liver toxicity in mice. Liver Internat. 2012, 32, 58.
Zhang Y.; Csanaky I. L.; Lehman-McKeeman L. D.; Klaassen C. D. Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid hepatotoxicity in mice by increasing intestinal permeability. Toxicol. Sci. 2011, 124, 251.
Zhang Y.; Klaassen C. D. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J. Lipid Res. 2010, 51, 3230.
ResearcherID Publications
Year Title Author(s) Source Volume
2011 MOUSE STRAIN DIFFERENCES IN BILE ACID HOMEOSTASIS Csanaky, Ivan L.; Zhang, Youcai; Klaassen, Curtis D. Hepatology 54
2011 NUTRIENT REGULATION OF CYP7A1 EXPRESSION LINKS BILE ACID SYNTHESIS TO MAINTAIN METABOLIC HOMEOSTASIS AND PREVENT DIABETES AND OBESITY Li, Tiangang; Boehme, Shannon M.; Ochoa, Adrian; et al. Hepatology 54
2011 Organic Anion-Transporting Polypeptide 1b2 (Oatp1b2) Is Important for the Hepatic Uptake of Unconjugated Bile Acids: Studies in Oatp1b2-Null Mice Csanaky, Ivan L.; Lu, Hong; Zhang, Youcai; et al. Hepatology 53
2010 Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice Zhang, Youcai; Klaassen, Curtis D. Journal of Lipid Research 51
2008 Synthesis, structure and nonlinear optical properties of three dimensional compounds Pan, Zhao Rui; Zhang, You Cai; Song, Ying Lin; et al. Journal of Coordination Chemistry 61
2008 The Nrf2 activator oltipraz also activates the constitutive androstane receptor Merrell, Matthew D.; Jackson, Jonathan P.; Augustine, Lisa M.; et al. Drug Metabolism and Disposition 36
2006 Bis(2,2 ’-bipyridine)iodo(oxo)tri-mu(3)-sulfido-tricopper(I)tungsten(VI) Li, WG; Zhang, YC; Wang, ZW; et al. Acta Crystallographica Section C-Crystal Structure Communications 62
2005 Recent progress on Mo(W)/Cu(Ag,Au)/S heterothiometallic polymeric clusters Zhang, YC; Liang, K; Chen, QY; et al. Chinese Journal of Inorganic Chemistry 21
2004 A new type of [2] and [3]pseudorotaxane composed of beta-cyclodextrin and bisimidazolyl compounds Shen, XJ; Chen, HL; Yu, F; et al. Tetrahedron Letters 45
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