Home / People / Faculty / Chang Chung

Chang Chung——Professor

Room A304, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
Group weblink
Education Experience
1990-1995 Ph. D. Duke University, NC, USA
1995-1997 Postdoctoral University of California, San Diego, USA
Professional Experience
1996-1998 Teaching Assistant Seoul National University, Seoul, Korea
1991-1994 Research Assistant Duke University, Durham, NC USA
1995-1997 Postdoctoral Fellow UC-San Diego, San Diego, CA USA
1997-2001 Assistant Project Scientist UCSD
2001-2009 Assistant Professor Vanderbilt University Medical Center
2005-2014 Faculty Fellow Biosystems Research and Education
2009-2014 Associate Professor with tenure Vanderbilt University Medical Center
2015- Professor Tianjin University
Research Area

The research in the Chung group focuses on understanding the role of microglia in neuroinflammation. Inflammation is a key component of pathophysiology of both acute injuries and chronic diseases including Parkinson’s and Alzheimer’s. Microglia activation/chemotaxis is prerequisite for microglia function whether neuroprotective or inflammatory, making understanding essential for design of rational approaches for therapeutic modulation and regulation of microglia proliferation and chemotaxis.  Emphasis is on control of activation/chemotaxis of resident microglia in the brain in early stages of neuroinflammation.  Unraveling complex networks of signaling downstream of P2Y12 receptor during microglia chemotaxis is an important target.  Elucidation of neurotoxic effects of microglia observed in depression is another area of research interests.

Honors and Awards
Kyemong Fellowship: 1982-1986
Ministry of Education Grant-in-Aid of Research: 1986-1988
American Society of Cell Biology Student Travel Award: 1994
Duke University Graduate School Fellowship: 1990 - 1995
Special Fellow Award from the Leukemia and Lymphoma Society 2000-2003
NIH/NIGMS (RO1 GM068097), Principal Investigator: Chang Chung, 2003 – 2014
American Heart Association Grant-in-Aid (0655167B): Principal Investigator: Chang Chung, 2006 – 2008
Teaching Award, SPST, Tianjin University, 2015
Wikswo, John P.; Baudenbacher, Franz J.; Prokop, Ales; LeBoeuf, Eugene; Chung, Chang Y.; Cliffel, David E.; Haselton, Frederick R.; Hofmeister, William H.; Lin, Charles P.; McCawley, Lisa J.; Reiserer, Randall S.; and Stremler, Mark A., to Vanderbilt University. Capillary perfused bioreactors with multiple chambers 08003378 Cl. 435-289.1.
Highlighted Publications
Lee, S. and C.Y. Chung (2009). Role of VASP phophorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation. Molecular Cellular Neuroscience 42:382-390
Yang Fan, Zhilu Chen, Janak Pathak, Ana Carneiro, and Chang Y. Chung (2018). Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine. Front. Cell. Neurosci. 12:309
Sang-Hyun Lee, Neetu Sud, Narae Lee, Chang Y. Chung (2016). Regulation of Integrin a6 Recycling by iPLA2 to Promote Microglia Chemotaxis on Laminin. J. Biol. Chem. 291:23645-23653
Lee, S.-H.; Hollingsworth, R.; Kwon, H.-Y.; Chung, C.-Y. (2012) β-Arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser83 and microglia chemotaxis. Glia 60, 1366.
Lee, S.; Schneider, C.; Higdon, A. N.; Darley-Usmar , V. M.; Chung, C. Y. (2011) Role of iPLA2 in the regulation of Src trafficking and microglia chemotaxis. Traffic 12, 878.
Myers, S.; Han, J.; Lee, Y.; Firtel, R. A.; Chung, C. Y. (2005) A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol. Biol. Cell 16, 2191.
Chung, C. Y.; Potikyan, G.; Firtel, R. A. (2001) Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7, 937.
Chung, C.; Reddy, T. B. K.; Zhou, K.; Firtel, R. A. (1998) A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation. Genes Devel. 12, 3564.
ResearcherID Publications
Year Title Author(s) Source Volume
2018 Bisphenol A (BPA) the mighty and the mutagenic. Jalal, Nasir; Surendranath, Austin R; Pathak, Janak L; et al. Toxicology reports 5
2017 ADP-ribosylation of vimentin induces changes in morphology and motility of microglia through enhancing phosphorylation of vimentin at Ser(56) and disassembly of vimentin filaments. Xie, L.; Yang, F.; Chung, C. Y. Molecular Biology of the Cell 28
2017 Role of Calcium-Independent Phospholipase A2 VIA in Mediating Neurological Disorder and Cancer Chung, Chang Y.; Shi, Yu; Surendranath, Austin R.; et al. Transactions of Tianjin University 23
2017 Signaling Pathways Controlling Microglia Chemotaxis Yang, Fan; Lirui, Xie; and Chang, Y. Chung Mol. Cells 40
2016 Regulation of Integrin α6 Recycling by Calcium-independent Phospholipase A2 (iPLA2) to Promote Microglia Chemotaxis on Laminin Lee, Sang-Hyun; Sud, Neetu; Lee, Narae; et al. Journal of Biological Chemistry 291
2016 Regulation of iPLA2 Activity and Localization by Rab5. Shi, Y.; Chung, D.; Chung, C. Y. Molecular Biology of the Cell 27
2015 Adenylyl cyclase localization to the uropod of aggregating Dictyostelium cells requires RacC. Wang, C; Jung, D; Cao, Z; et al. Biochemical and biophysical research communications 465
2014 Pro32Pro33 Mutations in the Integrin beta(3) PSI Domain Result in alpha IIb beta(3) Priming and Enhanced Adhesion: Reversal of the Hypercoagulability Phenotype by the Src Inhibitor SKI-606 Oliver, Kendra H.; Jessen, Tammy; Crawford, Emily L.; et al. Molecular Pharmacology 85
2013 An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis Chung, Chang Y.; Feoktistov, Alexander; Hollingsworth, Ryan J.; et al. Biochemical and Biophysical Research Communications 436
2013 Basophile: Accurate Fragment Charge State Prediction Improves Peptide Identification Rates Wang, Dong; Dasari, Surendra; Chambers, Matthew C.; et al. Genomics Proteomics & Bioinformatics 11
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