Home / People / Faculty / Chang Chung

Chang Chung——Professor

Room A304, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
Group weblink
Education Experience
1990-1995 Ph. D. Duke University, NC, USA
1995-1997 Postdoctoral University of California, San Diego, USA
Professional Experience
1996-1998 Teaching Assistant Seoul National University, Seoul, Korea
1991-1994 Research Assistant Duke University, Durham, NC USA
1995-1997 Postdoctoral Fellow UC-San Diego, San Diego, CA USA
1997-2001 Assistant Project Scientist UCSD
2001-2009 Assistant Professor Vanderbilt University Medical Center
2005-2014 Faculty Fellow Biosystems Research and Education
2009-2014 Associate Professor with tenure Vanderbilt University Medical Center
2015- Professor Tianjin University
Research Area

The research in the Chung group focuses on understanding the role of microglia in neuroinflammation. Inflammation is a key component of pathophysiology of both acute injuries and chronic diseases including Parkinson’s and Alzheimer’s. Microglia activation/chemotaxis is prerequisite for microglia function whether neuroprotective or inflammatory, making understanding essential for design of rational approaches for therapeutic modulation and regulation of microglia proliferation and chemotaxis.  Emphasis is on control of activation/chemotaxis of resident microglia in the brain in early stages of neuroinflammation.  Unraveling complex networks of signaling downstream of P2Y12 receptor during microglia chemotaxis is an important target.  Elucidation of neurotoxic effects of microglia observed in depression is another area of research interests.

Honors and Awards
Kyemong Fellowship: 1982-1986
Ministry of Education Grant-in-Aid of Research: 1986-1988
American Society of Cell Biology Student Travel Award: 1994
Duke University Graduate School Fellowship: 1990 - 1995
Special Fellow Award from the Leukemia and Lymphoma Society 2000-2003
NIH/NIGMS (RO1 GM068097), Principal Investigator: Chang Chung, 2003 – 2014
American Heart Association Grant-in-Aid (0655167B): Principal Investigator: Chang Chung, 2006 – 2008
Teaching Award, SPST, Tianjin University, 2015
Wikswo, John P.; Baudenbacher, Franz J.; Prokop, Ales; LeBoeuf, Eugene; Chung, Chang Y.; Cliffel, David E.; Haselton, Frederick R.; Hofmeister, William H.; Lin, Charles P.; McCawley, Lisa J.; Reiserer, Randall S.; and Stremler, Mark A., to Vanderbilt University. Capillary perfused bioreactors with multiple chambers 08003378 Cl. 435-289.1.
Highlighted Publications
Lee, S. and C.Y. Chung (2009). Role of VASP phophorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation. Molecular Cellular Neuroscience 42:382-390
Yang Fan, Zhilu Chen, Janak Pathak, Ana Carneiro, and Chang Y. Chung (2018). Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine. Front. Cell. Neurosci. 12:309
Sang-Hyun Lee, Neetu Sud, Narae Lee, Chang Y. Chung (2016). Regulation of Integrin a6 Recycling by iPLA2 to Promote Microglia Chemotaxis on Laminin. J. Biol. Chem. 291:23645-23653
Lee, S.-H.; Hollingsworth, R.; Kwon, H.-Y.; Chung, C.-Y. (2012) β-Arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser83 and microglia chemotaxis. Glia 60, 1366.
Lee, S.; Schneider, C.; Higdon, A. N.; Darley-Usmar , V. M.; Chung, C. Y. (2011) Role of iPLA2 in the regulation of Src trafficking and microglia chemotaxis. Traffic 12, 878.
Myers, S.; Han, J.; Lee, Y.; Firtel, R. A.; Chung, C. Y. (2005) A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol. Biol. Cell 16, 2191.
Chung, C. Y.; Potikyan, G.; Firtel, R. A. (2001) Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7, 937.
Chung, C.; Reddy, T. B. K.; Zhou, K.; Firtel, R. A. (1998) A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation. Genes Devel. 12, 3564.
ResearcherID Publications
Year Title Author(s) Source Volume
2006 Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium Han, Ji W.; Leeper, Laura; Rivero, Francisco; et al. Journal of Biological Chemistry 281
2006 WASP-interacting protein is important for actin filament elongation and prompt pseudopod formation in response to a dynamic chemoattractant gradient Myers, Scott A.; Leeper, Laura R.; Chung, Chang Y. Molecular Biology of the Cell 17
2005 A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis Myers, SA; Han, JW; Lee, Y; et al. Molecular Biology of the Cell 16
2005 Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator Walker, GM; Sai, JQ; Richmond, A; et al. Lab on a Chip 5
2004 Role of RacC for the regulation of WASP activity during chemotaxis of Dictyostelium Han, JW; Leeper, L; Rivero, F; et al. Molecular Biology of the Cell 15
2002 Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium Han, YH; Chung, CY; Wessels, D; et al. Journal of Biological Chemistry 277
2002 Role of WASP in controlling f-actin assembly and motility during Dictyostelium chemotaxis Chung, CY; Myers, SA; Firtel, RA Molecular Biology of the Cell 13
2002 Signaling pathways at the leading edge of chemotaxing cells Chung, CY; Firtel, RA Journal of Muscle Research and Cell Motility 23
2001 Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa Chung, CY; Potikyan, G; Firtel, RA Molecular Cell 7
2001 Signaling pathways controlling cell polarity and chemotaxis Chung, CY; Funamoto, S; Firtel, RA Trends in Biochemical Sciences 26
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