Home / People / Faculty / Chang Chung

Chang Chung——Professor

Nationality:
USA
Phone:
022-27401105
Email:
cychung@tju.edu.cn
Office:
Room A304, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
1990-1995 Ph. D. Duke University, NC, USA
1995-1997 Postdoctoral University of California, San Diego, USA
Professional Experience
1996-1998 Teaching Assistant Seoul National University, Seoul, Korea
1991-1994 Research Assistant Duke University, Durham, NC USA
1995-1997 Postdoctoral Fellow UC-San Diego, San Diego, CA USA
1997-2001 Assistant Project Scientist UCSD
2001-2009 Assistant Professor Vanderbilt University Medical Center
2005-2014 Faculty Fellow Biosystems Research and Education
2009-2014 Associate Professor with tenure Vanderbilt University Medical Center
2015- Professor Tianjin University
Research Area

The research in the Chung group focuses on understanding the role of microglia in neuroinflammation. Inflammation is a key component of pathophysiology of both acute injuries and chronic diseases including Parkinson’s and Alzheimer’s. Microglia activation/chemotaxis is prerequisite for microglia function whether neuroprotective or inflammatory, making understanding essential for design of rational approaches for therapeutic modulation and regulation of microglia proliferation and chemotaxis.  Emphasis is on control of activation/chemotaxis of resident microglia in the brain in early stages of neuroinflammation.  Unraveling complex networks of signaling downstream of P2Y12 receptor during microglia chemotaxis is an important target.  Elucidation of neurotoxic effects of microglia observed in depression is another area of research interests.

Honors and Awards
Kyemong Fellowship: 1982-1986
Ministry of Education Grant-in-Aid of Research: 1986-1988
American Society of Cell Biology Student Travel Award: 1994
Duke University Graduate School Fellowship: 1990 - 1995
Special Fellow Award from the Leukemia and Lymphoma Society 2000-2003
NIH/NIGMS (RO1 GM068097), Principal Investigator: Chang Chung, 2003 – 2014
American Heart Association Grant-in-Aid (0655167B): Principal Investigator: Chang Chung, 2006 – 2008
Teaching Award, SPST, Tianjin University, 2015
Patents
Wikswo, John P.; Baudenbacher, Franz J.; Prokop, Ales; LeBoeuf, Eugene; Chung, Chang Y.; Cliffel, David E.; Haselton, Frederick R.; Hofmeister, William H.; Lin, Charles P.; McCawley, Lisa J.; Reiserer, Randall S.; and Stremler, Mark A., to Vanderbilt University. Capillary perfused bioreactors with multiple chambers 08003378 Cl. 435-289.1.
Highlighted Publications
Lee, S. and C.Y. Chung (2009). Role of VASP phophorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation. Molecular Cellular Neuroscience 42:382-390
Yang Fan, Zhilu Chen, Janak Pathak, Ana Carneiro, and Chang Y. Chung (2018). Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine. Front. Cell. Neurosci. 12:309
Sang-Hyun Lee, Neetu Sud, Narae Lee, Chang Y. Chung (2016). Regulation of Integrin a6 Recycling by iPLA2 to Promote Microglia Chemotaxis on Laminin. J. Biol. Chem. 291:23645-23653
Lee, S.-H.; Hollingsworth, R.; Kwon, H.-Y.; Chung, C.-Y. (2012) β-Arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser83 and microglia chemotaxis. Glia 60, 1366.
Lee, S.; Schneider, C.; Higdon, A. N.; Darley-Usmar , V. M.; Chung, C. Y. (2011) Role of iPLA2 in the regulation of Src trafficking and microglia chemotaxis. Traffic 12, 878.
Myers, S.; Han, J.; Lee, Y.; Firtel, R. A.; Chung, C. Y. (2005) A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol. Biol. Cell 16, 2191.
Chung, C. Y.; Potikyan, G.; Firtel, R. A. (2001) Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7, 937.
Chung, C.; Reddy, T. B. K.; Zhou, K.; Firtel, R. A. (1998) A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation. Genes Devel. 12, 3564.
ResearcherID Publications
Year Title Author(s) Source Volume
2000 Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells Chung, CY; Lee, S; Briscoe, C; et al. Proceedings of the National Academy of Sciences of the United States of America 97
2000 The Dictyostelium LIM domain-containing protein LIM2 is essential for proper chemotaxis and morphogenesis Chien, S; Chung, CY; Sukumaran, S; et al. Molecular Biology of the Cell 11
2000 The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients Firtel, RA; Chung, CY Bioessays 22
1999 PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis Chung, CY; Firtel, RA Journal of Cell Biology 147
1999 Serum levels of insulin-like growth factor (IGF)-I, free IGF-I, IGF binding protein (IGFBP)-1, IGFBP-3 and insulin in obese children Park, MJ; Kim, HS; Kang, JH; et al. Journal of Pediatric Endocrinology & Metabolism 12
1998 A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation Chung, CY; Reddy, TBK; Zhou, KM; et al. Genes & Development 12
1997 Effect of the distraction rate on the activity of the osteoblast lineage in distraction osteogenesis of rat’s tibia. Immunostaining study of the proliferating cell nuclear antigen, osteocalcin, and transglutaminase C. Choi, I H; Shim, J S; Seong, S C; et al. Bulletin (Hospital for Joint Diseases (New York, N.Y.)) 56
1997 Glycosaminoglycans modulate fibronectin matrix assembly and are essential for matrix incorporation of tenascin-C Chung, CY; Erickson, HP Journal of Cell Science 110
1996 Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II Chung, CY; MurphyUllrich, JE; Erickson, HP Molecular Biology of the Cell 7
1995 BINDING OF TENASCIN-C TO SOLUBLE FIBRONECTIN AND MATRIX FIBRILS CHUNG, CY; ZARDI, L; ERICKSON, HP Journal of Biological Chemistry 270
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