Home / People / Faculty / Jun Dai

Jun Dai ——Associate Professor

Nationality:
CHINA
Phone:
022-87401830
Email:
jun.dai@tju.edu.cn
Office:
Room A303, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
2000 Ph. D. Tulane University, LA
2000 Postdoctoral Brigham and Womens Hospital, Boston, MA
Professional Experience
2008-2014 Instructor in Dermatology Massachusetts General Hospital/Harvard Medical School
2005-2008 Instructor in Medicine Brigham and Women’s Hospital/Harvard Medical School
2000-2005 Postdoctoral Fellow Brigham and Women’s Hospital, Boston, MA
Research Area

The research efforts of the Dai group encompass two areas:  1) The role of retinoid-related orphan receptor RORα in controlling skin homeostatis, and 2) Control of normal mitosis by protein kinase haspin.  In the first area, the main interest is on the interplay between intra- and inter-cellular signaling pathways involved in control of skin tissue homeostasis and tumor development. Focuses on the role of the nuclear orphan receptor RORα in controlling keratinocyte differentiation and skin tumor formation, as well as the therapeutic potential of RORα agonists/antagonists in treatment of skin diseases.  In the second area, the group is interested in exploring the role of haspin in cancer development and the potential of haspin inhibitors as anti-tumor drugs.

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Honors and Awards
Patents
Highlighted Publications
Dai, J.; Brooks, Y.; Lefort, K.; Getsios, S.; Dotto, G. P. The retinoid-related orphan receptor RORα promotes keratinocyte differentiation via FOXN1. PLoS ONE 2013, 8, e70392.
Wang, F.; Dai, J.; Daum, J. R.; Niedzialkowska E.; Banerjee B.; Stukenberg T.; Gorbsky G. J.; Higgins, J. M. Histone H3 Thr-3 phosphorylation by haspin positions Aurora B at centromeres in mitosis. Science 2010, 330, 231.
Dai, J.; Kateneva, A. V.; Higgins, J. M. Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion. J. Cell Sci. 2009, 122, 4148.
Dai, J.; Sullivan, B. A.; Higgins, J. M. Regulation of mitotic chromosome cohesion by haspin and aurora B. Dev. Cell 2006; 11, 741. (Featured cover illustration)
Dai, J.; Sultan, S.; Taylor, S. S.; Higgins, J. M. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes & Dev. 2005, 19, 472. (Featured cover illustration)
ResearcherID Publications
Year Title Author(s) Source Volume
2014 Multifactorial ER beta and NOTCH1 control of squamous differentiation and cancer Brooks, Yang Sui; Ostano, Paola; Jo, Seung-Hee; et al. Journal of Clinical Investigation 124
2013 The Retinoid-Related Orphan Receptor ROR alpha Promotes Keratinocyte Differentiation via FOXN1 Dai, Jun; Brooks, Yang; Lefort, Karine; et al. Plos One 8
2010 Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis Wang, Fangwei; Dai, Jun; Daum, John R.; et al. Science 330
2010 Melatonin inhibits mitogenic cross-talk between retinoic acid-related orphan receptor alpha (ROR alpha) and ER alpha in MCF-7 human breast cancer cells Dong, Chunmin; Yuan, Lin; Dai, Jun; et al. Steroids 75
2009 Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion Dai, Jun; Kateneva, Anna V.; Higgins, Jonathan M. G. Journal of Cell Science 122
2007 An ACAP1-containing clathrin coat complex for endocytic recycling Li, Jian; Peters, Peter J.; Bai, Ming; et al. Journal of Cell Biology 178
2006 Regulation of mitotic chromosome cohesion by Haspin and Aurora B Dai, Jun; Sullivan, Beth A.; Higgins, Jonathan M. G. Developmental Cell 11
2005 Haspin - A mitotic histone kinase required for metaphase chromosome alignment Dai, J; Higgins, JMG Cell Cycle 4
2005 Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta 1 to control cell migration Li, J; Ballif, BA; Powelka, AM; et al. Developmental Cell 9
2005 The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment Dai, J; Sultan, S; Taylor, SS; et al. Genes & Development 19
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