Home / People / Faculty / Tao Wang

Tao Wang——Professor

Nationality:
China
Phone:
Email:
wangtaobio@tju.edu.cn
Office:
92 Weijin Road, Nankai District, Tianjin
School:
School of Life Sciences
ResearcherID:
Group weblink
Education Experience
1990-1994 Bachelor of Science Department of Chemistry, Organic Chemistry Lanzhou University
1996-1999 M.S. School of Life Sciences, Biochemistry and Molecula Lanzhou University
2000-2003 Ph. D. Institute for Viral Disease Control, Pathogenic Bi Chinese CDC
2003-2004 Postdoctoral Weill Cornell Medical College, Biochemistry Cornell University
2004-2009 Postdoctoral School of Public Health, Molecular Microbiology an Johns Hopkins University
Professional Experience
1994-1996 Research fellow Ministry of Health Lanzhou Institute of Biologic Products, First Research Department (Dept. of Bacte
1999-2000 Research fellow Surveying-Designing Institute of Land Reclamation in Gansu Province
2009-2013 Professor Chinese CDC, Institute for Viral Disease Control
2013- Professor Tianjin University, School of Life Sciences
Research Area

Innate immunity is the first line of host defense against invading pathogenic microorganisms, where type I interferon (IFN) production is initiated at the early stages and subsequently induces the expression of IFN-stimulated genes (ISGs) in an autocrine and paracrine manner, leading to the destruction of invading pathogens. In order to replicate and survive, viruses have evolved diverse strategies to evade IFN responses. One area of research in my laboratory is to understand the molecular mechanisms of evasion of innate immunity by pathogenic microorganisms. 

Another goal of our research is to study the molecular mechanisms of severe fever with thrombocytopenia syndrome virus (SFTSV) and enteroviruss D68 pathogenesis.

Key scientific issues

1) Innate detection of viral pathogenic microorganisms;

2) The mechanism of ubiquitin in the antiviral signaling pathway;

3) The molecular mechanism of the generation and regulation of type I interferon and other important cytokines by natural immune activation;

4) The mechanism of cytokine secretion after natural immune activation;

Honors and Awards
Patents
Highlighted Publications
5. Tian CJ*, Wang T*, Yu XF, et al. Viral determinants of SRP RNA packaging into HIV-1 particles. Nucleic Acids Res. 2007; 35(21):7288-302. (* Co- first authors).
4. Wang T, Tian CJ, Yu XF, et al. 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G. J Virol. 2007 Dec; 81(23):13112-24.
Wang T, Tian CJ, Yu XF, et al. Interaction with 7SL RNAs but not HIV-1 genomic RNA or P-bodies is a critical determinant of APOBEC3F virion packaging. J Mol Biol. 2008 Jan 25; 375(4):1098-112.
2. Wang T, Tian CJ, Yu XF, et al. Distinct packaging mechanisms of human cytidine deaminase APOBEC3 proteins into HIV-1 virions . Virology. 2008 Jul 20; 377(1):71-9.
1. Zhen A*, Wang T*, Yong Xiong, Yu XF. A single amino acid difference in human APOBEC3H variants determines HIV-1 Vif sensitivity. J Virol. 2010 Feb;84(4):1902-11. Epub 2009 Nov 25. (* Co- first authors)
ResearcherID Publications
Year Title Author(s) Source Volume
2014 [Severe fever with thrombocytopenia syndrome virus nucleoprotein specifically binds to 60kD SSA/Ro protein in host cells]. Zheng, Bin; Wang, Tao; Zhang, Shuo; et al. Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] 30
2013 Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid Protein in Complex with Suramin Reveals Therapeutic Potential Jiao, Lianying; Ouyang, Songying; Liang, Mifang; et al. Journal of Virology 87
2012 Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model Jin, Cong; Liang, Mifang; Ning, Junyu; et al. Proceedings of the National Academy of Sciences of the United States of America 109
2012 [Establishment of minireplicon system for severe fever with thrombocytopenia syndrome bunyavirus]. Yu, Xia-Li; Jiang, Xiao-Lin; Wang, Tao; et al. Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] 28
2011 Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China Yu, Xue-Jie; Liang, Mi-Fang; Zhang, Shou-Yin; et al. New England Journal of Medicine 364
2011 [Expression of structural and non-structural proteins of severe fever with thrombocytopenia syndrome bunyavirus]. Lu, Jing; Li, Chuan; Zhang, Fu-Shun; et al. Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui] 27
2010 A Single Amino Acid Difference in Human APOBEC3H Variants Determines HIV-1 Vif Sensitivity Zhen, Anjie; Wang, Tao; Zhao, Ke; et al. Journal of Virology 84
2010 Hantavirus-like particles generated in CHO cells induce specific immune responses in C57BL/6 mice Li, Chuan; Liu, Feng; Liang, Mifang; et al. Vaccine 28
2010 Interactions of SARS Coronavirus Nucleocapsid Protein with the host cell proteasome subunit p42 Wang, Qin; Li, Chuan; Zhang, Quanfu; et al. Virology Journal 7
2010 Tracking hantavirus nucleocapsid protein using intracellular antibodies Li, Jiandong; Zhang, Quanfu; Wang, Tao; et al. Virology Journal 7
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