Home / People / Faculty / Tao Wang

Tao Wang——Professor

Nationality:
China
Phone:
Email:
wangtaobio@tju.edu.cn
Office:
92 Weijin Road, Nankai District, Tianjin
School:
School of Life Sciences
ResearcherID:
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Education Experience
1990-1994 Bachelor of Science Department of Chemistry, Organic Chemistry Lanzhou University
1996-1999 M.S. School of Life Sciences, Biochemistry and Molecula Lanzhou University
2000-2003 Ph. D. Institute for Viral Disease Control, Pathogenic Bi Chinese CDC
2003-2004 Postdoctoral Weill Cornell Medical College, Biochemistry Cornell University
2004-2009 Postdoctoral School of Public Health, Molecular Microbiology an Johns Hopkins University
Professional Experience
1994-1996 Research fellow Ministry of Health Lanzhou Institute of Biologic Products, First Research Department (Dept. of Bacte
1999-2000 Research fellow Surveying-Designing Institute of Land Reclamation in Gansu Province
2009-2013 Professor Chinese CDC, Institute for Viral Disease Control
2013- Professor Tianjin University, School of Life Sciences
Research Area

Innate immunity is the first line of host defense against invading pathogenic microorganisms, where type I interferon (IFN) production is initiated at the early stages and subsequently induces the expression of IFN-stimulated genes (ISGs) in an autocrine and paracrine manner, leading to the destruction of invading pathogens. In order to replicate and survive, viruses have evolved diverse strategies to evade IFN responses. One area of research in my laboratory is to understand the molecular mechanisms of evasion of innate immunity by pathogenic microorganisms. 

Another goal of our research is to study the molecular mechanisms of severe fever with thrombocytopenia syndrome virus (SFTSV) and enteroviruss D68 pathogenesis.

Key scientific issues

1) Innate detection of viral pathogenic microorganisms;

2) The mechanism of ubiquitin in the antiviral signaling pathway;

3) The molecular mechanism of the generation and regulation of type I interferon and other important cytokines by natural immune activation;

4) The mechanism of cytokine secretion after natural immune activation;

Honors and Awards
Patents
Highlighted Publications
5. Tian CJ*, Wang T*, Yu XF, et al. Viral determinants of SRP RNA packaging into HIV-1 particles. Nucleic Acids Res. 2007; 35(21):7288-302. (* Co- first authors).
4. Wang T, Tian CJ, Yu XF, et al. 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G. J Virol. 2007 Dec; 81(23):13112-24.
Wang T, Tian CJ, Yu XF, et al. Interaction with 7SL RNAs but not HIV-1 genomic RNA or P-bodies is a critical determinant of APOBEC3F virion packaging. J Mol Biol. 2008 Jan 25; 375(4):1098-112.
2. Wang T, Tian CJ, Yu XF, et al. Distinct packaging mechanisms of human cytidine deaminase APOBEC3 proteins into HIV-1 virions . Virology. 2008 Jul 20; 377(1):71-9.
1. Zhen A*, Wang T*, Yong Xiong, Yu XF. A single amino acid difference in human APOBEC3H variants determines HIV-1 Vif sensitivity. J Virol. 2010 Feb;84(4):1902-11. Epub 2009 Nov 25. (* Co- first authors)
ResearcherID Publications
Year Title Author(s) Source Volume
2009 A Patch of Positively Charged Amino Acids Surrounding the Human Immunodeficiency Virus Type 1 Vif SLVx4Yx9Y Motif Influences Its Interaction with APOBEC3G Chen, Gongying; He, Zhiwen; Wang, Tao; et al. Journal of Virology 83
2009 Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase Ehrlich, Elana S.; Wang, Tao; Luo, Kun; et al. Proceedings of the National Academy of Sciences of the United States of America 106
2008 Conserved and non-conserved features of HIV-1 and SIVagm Vif mediated suppression of APOBEC3 cytidine deaminases Zhang, Wenyan; Huang, Michael; Wang, Tao; et al. Cellular Microbiology 10
2008 Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression Zhang, Wei; Zhang, Xuzhao; Tian, C.; et al. Cellular Microbiology 10
2008 Distinct viral determinants for the packaging of human cytidine deaminases APOBEC3G and APOBEC3C Wang, Tao; Zhang, Wenyan; Tian, Chunjuan; et al. Virology 377
2008 Interaction with 7SL RNA but not with HIV-1 genomic RNA or p bodies is required for APOBEC3F virion packaging Wang, Tao; Tian, Chunjuan; Zhang, Wenyan; et al. Journal of Molecular Biology 375
2007 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G Wang, Tao; Tian, Chunjuan; Zhang, Wenyan; et al. Journal of Virology 81
2007 Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation Luo, Kun; Wang, Tao; Liu, Bindong; et al. Journal of Virology 81
2007 Differential inhibition of long interspersed element 1 by APOBEC3 does not correlate with high-molecular-mass-complex formation or P-body association Niewiadomska, Anna Maria; Tian, Chunjuan; Tan, Lindi; et al. Journal of Virology 81
2007 Virion packaging determinants and reverse transcription of SRP RNA in HIV-1 particles Tian, Chunjuan; Wang, Tao; Zhang, Wenyan; et al. Nucleic Acids Research 35
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