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Zhi Lin ——Professor

Building 15, Tianjin University
School of Life Sciences
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Education Experience
1994-1998 Bachelor of Science Biotechnology Xiamen University
1998-2001 M.S. Biochemistry & Molecular Biolology Xiamen University
2002-2006 Ph. D. Structural Biology National University of Singapore
2007-2009 Postdoctoral Structural Biology National University of Singapore
Professional Experience
2006-2007 Research Assistant National University of Singapore
2009-2012 Research Fellow National University of Singapore
2012-2015 Senior Research Fellow National University of Singapore
2015-2016 Principle Investigator Tianjin University
2011-2016 Visiting Professor Ningxia Medical School
2015-2016 Visiting Senior Research Fellow National University of Singapore
Research Area

1. Bioengineering of spider fibroins

Spider silks are proteinaceous biopolymers with extraordinary physical properties and biomimetic potential. This research focuses on the structure-based engineering and design of silk fibroins for the production of artificial spider silks with desirable mechanical properties.

2. NMR structural & functional studies on p75NTR signaling

p75 neurotrophin receptor (p75NTR) is a member of the Tumor Necreosis Factor Superfamily and its signaling actively contributes to neurodegeneration. The aim of this project is to elucidate structural mechanisms of p75NTR signaling in the nervous system and to discover drugs for neurodegenerative diseases and nerve injury. 

Honors and Awards
Peiyang Scholar (O plan), Tianjin University
Chunhui Scholar, MOE, China, 2010-2012
Singapore Millennium Foundation Scholarship, Singapore 2007-2009
Excellent Graduate (Honor Title), Xiamen University, 1998
Highlighted Publications
Lin, Z., Xu, Y., Yang, S., and Yang, D. (2006). Sequence-specific assignment of aromatic resonances of uniformly 13C,15N-labeled proteins by using 13C- and 15N-edited NOESY spectra. Angew. Chem. Int. Ed. 45:1960-1963.
Lin, Z., Sriskanthadevan, S., Huang, H., Siu, C.H., and Yang, D. (2006). Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion. Nat Struct Mol Biol 13:1016-1022.
Lin, Z., Huang, W., Zhang, J., Fan, J.S., and Yang, D. (2009). Solution structure of eggcase silk protein and its implications for silk fiber formation. Proc Natl Acad Sci USA 106:8906-8911.
Lin, Z., Deng, Q., Liu, X.Y., and Yang, D. (2013). Engineered large spider eggcase silk protein for strong artificial fibers. Adv Mater 25:1216-1220.
Lin, Z., Tann, J.Y., Goh, E.T., Kelly, C., Lim, K.B., Gao, J.F., and Ibanez, C.F. (2015). Structural basis of death domain signaling in the p75 neurotrophin receptor. eLife 4:e11692
ResearcherID Publications
Year Title Author(s) Source Volume