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Ying Yang——Associate Professor

yangyingcn2002@163.com; yangy@tju.edu.cn
92 Weijin Road, Nankai District, Tianjin City, 300072
School of Life Sciences
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Education Experience
1991-1996 Bachelor of Science Medical Science/ Nutrition and Food Hygiene Norman Bethune University of Medical Science, Ji-L
1996-1999 M.S. Radiation Biology Norman Bethune University of Medical Science, Ji-L
1999-2002 Ph. D. Radiation Biology Jilin Universtiy, Ji-Lin, China
2007-2011 Postdoctoral Cancer Gene Therapy Columbia University, New York, USA
Professional Experience
1999-2001 Teaching Assistant Norman Bethune University of Medical Science, Jilin, China
2002-2004 Lecturer Jilin University, Jilin, China
2005-2010 Associate Professor Jilin University, Jilin, China
2011-2012 Research Associate Mount Sinai School of Medicine, New York USA
2013-2016 Associate Professor Tianjin University, Tianjin, China
Research Area

Human long interspersed elements 1 (LINE-1 or L1) is the only autonomous non-LTR retroelement in humans and has been associated with genome instability, inherited genetic diseases, and the development of cancer.  Certain human APOBEC3 family proteins are known to have LINE-1 restriction activity.  Our group focuses on exploring the mechanisms of APOBEC3 family proteins on LINE-1 restriction.  Some of A3 proteins interact with LINE-1 ORF1p to target LINE-1 ribonucleoprotein particles in an RNA-dependent manner and further Inhibit the LINE-1 reverse transcriptase activity. 

Figure Inhibitory effect of A3B and A3DE on LINE-1 mobility. The A3B- or A3DE-expressing vector was co-transfected with L1RP-EGFP, and flow cytometry was used to detect the EGFP-positive cells. Representative flow cytometry dot diagrams for A3B and A3DE in LINE-1 restriction. The percentage of EGFP-positive events is shown in the upper right corner of each panel.

Honors and Awards
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Highlighted Publications
Yang Y, Li XJ, Sun ZY, et al. Anti-tumor effects of B16 melanoma HSP-antigen peptide complex in vivo and in vitro (HAC). Chinese Journal of Cancer Biotherapy. 2000, 7(2): 121-123.
Yang Y, Fu SB, Li XJ, et al. Tumor inhibiting effects and its mechanism of HACs purified from B16 melanoma cells. Chinese Journal of Cancer. 2000, 19(9): 900-902.
Yang Y, Liu SZ, Fu SB. Biological activity of pNEgr-mIL-12 recombinant plasmid in vitro and in vivo. Prog. Biochem. Biophys. 2002, 29(5), 790-795.
Yang Y, Liu SZ, Fu SB. Anti-tumor effects of pNEgr-mIL-12 recombinant plasmid induced by X-irradiation and its mechanisms. Biomed. Environ. Sci. 2004, 17 (2): 135-143.
Yang Y, Wu J, Demir A, et al. GAB2 induced tumor angiogenesis in NRAS-driven melanoma. Oncogene. 2013, 32(31): 3627-37.
ResearcherID Publications
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