Home / People / Faculty / Ying Yang

Ying Yang——Associate Professor

Nationality:
China
Phone:
Email:
yangyingcn2002@163.com; yangy@tju.edu.cn
Office:
92 Weijin Road, Nankai District, Tianjin City, 300072
School:
School of Life Sciences
ResearcherID:
Group weblink
Education Experience
1991-1996 Bachelor of Science Medical Science/ Nutrition and Food Hygiene Norman Bethune University of Medical Science, Ji-L
1996-1999 M.S. Radiation Biology Norman Bethune University of Medical Science, Ji-L
1999-2002 Ph. D. Radiation Biology Jilin Universtiy, Ji-Lin, China
2007-2011 Postdoctoral Cancer Gene Therapy Columbia University, New York, USA
Professional Experience
1999-2001 Teaching Assistant Norman Bethune University of Medical Science, Jilin, China
2002-2004 Lecturer Jilin University, Jilin, China
2005-2010 Associate Professor Jilin University, Jilin, China
2011-2012 Research Associate Mount Sinai School of Medicine, New York USA
2013-2016 Associate Professor Tianjin University, Tianjin, China
Research Area

Human long interspersed elements 1 (LINE-1 or L1) is the only autonomous non-LTR retroelement in humans and has been associated with genome instability, inherited genetic diseases, and the development of cancer.  Certain human APOBEC3 family proteins are known to have LINE-1 restriction activity.  Our group focuses on exploring the mechanisms of APOBEC3 family proteins on LINE-1 restriction.  Some of A3 proteins interact with LINE-1 ORF1p to target LINE-1 ribonucleoprotein particles in an RNA-dependent manner and further Inhibit the LINE-1 reverse transcriptase activity. 

Figure Inhibitory effect of A3B and A3DE on LINE-1 mobility. The A3B- or A3DE-expressing vector was co-transfected with L1RP-EGFP, and flow cytometry was used to detect the EGFP-positive cells. Representative flow cytometry dot diagrams for A3B and A3DE in LINE-1 restriction. The percentage of EGFP-positive events is shown in the upper right corner of each panel.


Honors and Awards
List only pertinent awards here
Patents
List existing legitimate patents
Highlighted Publications
Yang Y, Li XJ, Sun ZY, et al. Anti-tumor effects of B16 melanoma HSP-antigen peptide complex in vivo and in vitro (HAC). Chinese Journal of Cancer Biotherapy. 2000, 7(2): 121-123.
Yang Y, Fu SB, Li XJ, et al. Tumor inhibiting effects and its mechanism of HACs purified from B16 melanoma cells. Chinese Journal of Cancer. 2000, 19(9): 900-902.
Yang Y, Liu SZ, Fu SB. Biological activity of pNEgr-mIL-12 recombinant plasmid in vitro and in vivo. Prog. Biochem. Biophys. 2002, 29(5), 790-795.
Yang Y, Liu SZ, Fu SB. Anti-tumor effects of pNEgr-mIL-12 recombinant plasmid induced by X-irradiation and its mechanisms. Biomed. Environ. Sci. 2004, 17 (2): 135-143.
Yang Y, Wu J, Demir A, et al. GAB2 induced tumor angiogenesis in NRAS-driven melanoma. Oncogene. 2013, 32(31): 3627-37.
ResearcherID Publications
Year Title Author(s) Source Volume