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Fumihiko Nakamura——Professor

B210, 2F Building 24, School of Pharmaceutical Science and Technology, Tianjin University
School of Pharmaceutical Science and Technology
Group weblink
Education Experience
1990-1993 Ph. D. Animal Science Tohoku University, Japan
1994-1995 Postdoctoral Cell Biology Stanford University
Professional Experience
1995-2000 Associate Professor Tohoku University
2001-2005 Research Fellow Brigham and Women's Hospital/Harvard Medical School
2006-2008 Instructor Brigham and Women's Hospital/Harvard Medical School
2008-2016 Assistant Professor Brigham and Women's Hospital/Harvard Medical School
2016- Professor Tianjin University
Research Area

The Nakamura group focuses on the regulation of the cellular actin cytoskeleton and in particular on the molecular mechanisms of chemical and mechanical signal transduction (mechanotransduction), a conversion of mechanical forces into cellular biochemical signals. Mechanotransduction is essential for many physiological processes in diverse organisms during development and maintenance of all tissues. Defects in mechanotransduction, often caused by mutations or deregulation of proteins that disturb cellular or extracellular mechanics, are implicated in the development of various diseases, ranging from muscular dystrophies and hypertension-induced vascular and cardiac hypertrophy to cancer progression and metastasis. Despite its importance, little is known about the underlying mechanisms of mechanotransduction. The group uses a wide range of techniques including proteomics, microscopy, molecular biology, and cell biology, and appreciate collaboration with expertises in structural biology, mechanical engineering, single molecular analysis, computer simulation, and drug design.

Lab intruduction figure for website.jpg

Honors and Awards
Japan society for the promotion of science for Japanese junior scientists
Nissan Science Foundation, Japan
Kurita Water and Environment Foundation, Japan
Naito Foundation, Japan
The HUSEC grant for an interdisciplinary seed proposal project, Harvard University, USA
Highlighted Publications
Song M, He Q, Berk BA, Hartwig JH, Stossel TP, *Nakamura F. An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu). Biochem Biophys Res Commun. 2016;469(3):659-64 PMID 26707877
*Nakamura F, Song M, Hartwig JH, Stossel TP. Documentation and localization of force-mediated filamin A domain perturbations in moving cells. Nat Commun. 2014;5:4656 PMID 25120197, PMC 4139033
*Nakamura F. FilGAP and its close relatives: a mediator of Rho-Rac antagonism that regulates cell morphology and migration. Biochem J. 2013;453(1):17-25 PMID 23763313
Ehrlicher AJ, *Nakamura F (co-first and corresponding author), Hartwig JH, Weitz DA, Stossel TP. Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature. 2011 PMID 21926999
Playford MP, Nurminen E, Pentikainen OT, Milgram SL, Hartwig JH, Stossel TP, *Nakamura F. Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A. J Biol Chem. 2010;285(22):17156-65 PMID 20351098, PMC 2878090
*Nakamura F, Osborn TM, Hartemink CA, Hartwig JH, Stossel TP. Structural basis of filamin A functions. J Cell Biol. 2007;179(5):1011-25 PMID 18056414
Nakamura F, Pudas R, Heikkinen O, Permi P, Kilpelainen I, Munday AD, Hartwig JH, Stossel TP, Ylanne J. The structure of the GPIb-filamin A complex. Blood. 2006;107(5):1925-32 PMID 16293600
Hishiya A, Ohnishi M, Tamura S, *Nakamura F. Protein phosphatase 2C inactivates F-actin binding of human platelet Moesin. J Biol Chem. 1999;274(38):26705-12
Nakamura F, Huang L, Pestonjamasp K, Luna EJ, Furthmayr H. Regulation of F-actin binding to platelet moesin In vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides. Mol Biol Cell. 1999;10(8):2669-85
ResearcherID Publications
Year Title Author(s) Source Volume
2010 Cystic Fibrosis Transmembrane Conductance Regulator Interacts with Multiple Immunoglobulin Domains of Filamin A Playford, Martin P.; Nurminen, Elisa; Pentikainen, Olli T.; et al. Journal of Biological Chemistry 285
2010 Filamin A is required for vimentin-mediated cell adhesion and spreading Kim, Hugh; Nakamura, Fumihiko; Lee, Wilson; et al. American Journal of Physiology-Cell Physiology 298
2010 Passive and active microrheology for cross-linked F-actin networks in vitro Lee, Hyungsuk; Ferrer, Jorge M.; Nakamura, Fumihiko; et al. Acta Biomaterialia 6
2010 Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin beta 1, and Contributes to Melanomagenesis Li, Chaoyang; Yu, Shuiliang; Nakamura, Fumihiko; et al. Journal of Biological Chemistry 285
2010 Regulation of cell adhesion to collagen via beta 1 integrins is dependent on interactions of filamin A with vimentin and protein kinase C epsilon Kim, Hugh; Nakamura, Fumihiko; Lee, Wilson; et al. Experimental Cell Research 316
2009 Activating mutations of N-WASP alter Shigella pathogenesis Adamovich, David A.; Nakamura, Fumihiko; Worth, Austen; et al. Biochemical and Biophysical Research Communications 384
2009 An active biopolymer network controlled by molecular motors Koenderink, Gijsje H.; Dogic, Zvonimir; Nakamura, Fumihiko; et al. Proceedings of the National Academy of Sciences of the United States of America 106
2009 Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer Li, Chaoyang; Yu, Shuiliang; Nakamura, Fumihiko; et al. Journal of Clinical Investigation 119
2009 Filamin A is essential for active cell stiffening but not passive stiffening under external force Kasza, K. E.; Nakamura, F.; Hu, S.; et al. Biophys J 96
2009 Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations Nakamura, Fumihiko; Heikkinen, Outi; Pentikaeinen, Olli T.; et al. Plos One 4