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Fumihiko Nakamura——Professor

B210, 2F Building 24, School of Pharmaceutical Science and Technology, Tianjin University
School of Pharmaceutical Science and Technology
Group weblink
Education Experience
1990-1993 Ph. D. Animal Science Tohoku University, Japan
1994-1995 Postdoctoral Cell Biology Stanford University
Professional Experience
1995-2000 Associate Professor Tohoku University
2001-2005 Research Fellow Brigham and Women's Hospital/Harvard Medical School
2006-2008 Instructor Brigham and Women's Hospital/Harvard Medical School
2008-2016 Assistant Professor Brigham and Women's Hospital/Harvard Medical School
2016- Professor Tianjin University
Research Area

The Nakamura group focuses on the regulation of the cellular actin cytoskeleton and in particular on the molecular mechanisms of chemical and mechanical signal transduction (mechanotransduction), a conversion of mechanical forces into cellular biochemical signals. Mechanotransduction is essential for many physiological processes in diverse organisms during development and maintenance of all tissues. Defects in mechanotransduction, often caused by mutations or deregulation of proteins that disturb cellular or extracellular mechanics, are implicated in the development of various diseases, ranging from muscular dystrophies and hypertension-induced vascular and cardiac hypertrophy to cancer progression and metastasis. Despite its importance, little is known about the underlying mechanisms of mechanotransduction. The group uses a wide range of techniques including proteomics, microscopy, molecular biology, and cell biology, and appreciate collaboration with expertises in structural biology, mechanical engineering, single molecular analysis, computer simulation, and drug design.

Lab intruduction figure for website.jpg

Honors and Awards
Japan society for the promotion of science for Japanese junior scientists
Nissan Science Foundation, Japan
Kurita Water and Environment Foundation, Japan
Naito Foundation, Japan
The HUSEC grant for an interdisciplinary seed proposal project, Harvard University, USA
Highlighted Publications
Song M, He Q, Berk BA, Hartwig JH, Stossel TP, *Nakamura F. An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu). Biochem Biophys Res Commun. 2016;469(3):659-64 PMID 26707877
*Nakamura F, Song M, Hartwig JH, Stossel TP. Documentation and localization of force-mediated filamin A domain perturbations in moving cells. Nat Commun. 2014;5:4656 PMID 25120197, PMC 4139033
*Nakamura F. FilGAP and its close relatives: a mediator of Rho-Rac antagonism that regulates cell morphology and migration. Biochem J. 2013;453(1):17-25 PMID 23763313
Ehrlicher AJ, *Nakamura F (co-first and corresponding author), Hartwig JH, Weitz DA, Stossel TP. Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature. 2011 PMID 21926999
Playford MP, Nurminen E, Pentikainen OT, Milgram SL, Hartwig JH, Stossel TP, *Nakamura F. Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A. J Biol Chem. 2010;285(22):17156-65 PMID 20351098, PMC 2878090
*Nakamura F, Osborn TM, Hartemink CA, Hartwig JH, Stossel TP. Structural basis of filamin A functions. J Cell Biol. 2007;179(5):1011-25 PMID 18056414
Nakamura F, Pudas R, Heikkinen O, Permi P, Kilpelainen I, Munday AD, Hartwig JH, Stossel TP, Ylanne J. The structure of the GPIb-filamin A complex. Blood. 2006;107(5):1925-32 PMID 16293600
Hishiya A, Ohnishi M, Tamura S, *Nakamura F. Protein phosphatase 2C inactivates F-actin binding of human platelet Moesin. J Biol Chem. 1999;274(38):26705-12
Nakamura F, Huang L, Pestonjamasp K, Luna EJ, Furthmayr H. Regulation of F-actin binding to platelet moesin In vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides. Mol Biol Cell. 1999;10(8):2669-85
ResearcherID Publications
Year Title Author(s) Source Volume
2009 Nonlinear elasticity of stiff biopolymers connected by flexible linkers Kasza, K. E.; Koenderink, G. H.; Lin, Y. C.; et al. Phys Rev E Stat Nonlin Soft Matter Phys 79
2009 Passive and active microrheology for cross-linked F-actin networks in vitro Lee, H.; Ferrer, J. M.; Nakamura, F.; et al. Acta Biomater 6
2008 Measuring molecular rupture forces between single actin filaments and actin-binding proteins Ferrer, Jorge M.; Lee, Hyungsuk; Chen, Jiong; et al. Proceedings of the National Academy of Sciences of the United States of America 105
2007 Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity Weins, Astrid; Schiondorff, Johannes S.; Nakamura, Fumihiko; et al. Proceedings of the National Academy of Sciences of the United States of America 104
2007 Structural basis of filamin A functions Nakamura, Fumihiko; Osborn, Teresia M.; Hartemink, Christopher A.; et al. Journal of Cell Biology 179
2006 Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis Feng, Yuanyi; Chen, Ming Hui; Moskowitz, Ivan P.; et al. Proceedings of the National Academy of Sciences of the United States of America 103
2006 MEKK4 signaling regulates filamin expression and neuronal migration Sarkisian, Matthew R.; Bartley, Christopher M.; Chi, Hongbo; et al. Neuron 52
2006 Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells Gardel, ML; Nakamura, F; Hartwig, JH; et al. Proceedings of the National Academy of Sciences of the United States of America 103
2006 Stress-dependent elasticity of composite actin networks as a model for cell behavior Gardel, ML; Nakamura, F; Hartwig, J; et al. Physical Review Letters 96
2006 The structure of the GPIb-filamin A complex Nakamura, F; Pudas, R; Heikkinen, O; et al. Blood 107