Home / People / Postdoctorals / Pradeepraj Durairaj

Pradeepraj Durairaj——Post-Doctoral Researcher

Nationality:
INDIAN
Phone:
15522839204
Email:
dr.deepraj11@gmail.com
Office:
School of Pharmaceutical Science and Technology, Tianjin University, Building 24, Room 403, 92 Weijin Road, Nankai District Tianjin, 300072 China
School:
School of Pharmaceutical Science and Technology
ResearcherID:
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Education Experience
2003-2006 Bachelor of Science Botany Bharathidasan University, India
2006-2008 Master of Science Plant Biotechnology Bharathidasan University, India
2010-2015 Ph. D. Biochemistry Yeungnam University, South Korea
Professional Experience
2009-2009 Project Assistant Stress Physiology & Biotech Laboratory, Dept. of Plant Science, Bharathidasan University, India
2010-2015 Research Assistant Protein Engineering Laboratory, Dept of Biochemistry, Yeungnam University, South Korea
2015-2016 Post-Doctoral Research Associate Korean Lichen Research Institute, Sunchon National University, South Korea
Research Area

Cytochrome P450 (CYP) monooxygenases, the nature’s most versatile biological catalysts have unique ability to catalyse regio-, chemo-, and stereospecific oxidation of a wide range of substrates under mild reaction conditions, thereby addressing a significant challenge in chemocatalysis. In the recent decades, the importance of CYPs is illustrated by the fact that they are responsible for the majority of Phase I reactions in human drug metabolism, and their substrates include a broad range of active pharmaceutical ingredients, environmental toxins, carcinogens, and food-derived chemicals. Therefore, a compilation of CYP monooxygenases is required for a rational comprehensive approach for elucidating the catalytic potentials and functional utilities of human CYPs for industrial approach. This urged us to generate the gene library of human cytochrome P450s to facilitate the glimpse of molecular mechanisms and metabolic diversity of P450s, thereby functionally explore and characterize the novel enzymes.  Here I have listed the three major ongoing projects which I am currently engaged in Prof. Bureik's laboratory. 

1.      Construction of Human CYP Gene Library

2.      Functional Expression of Human CYPs in Fission Yeast Reconstituted System

3.      Systematic assessment of CYP-dependent metabolism with Differential Redox partners




 

Honors and Awards
Awarded the outstanding “Foreign Young Talent Program” sponsorship by the State Administration of Foreign Experts Affairs (SAFEA), P.R.China (2017-2018).
Recipient of prestigious "Korean Government Scholarship Program" granted by National Institute for International Education to pursue Doctoral Research studies in South Korea (Sep 2009 - Aug 2014).
Secured University Fifth Rank in B.Sc. Degree Examinations conducted by Bharathidasan University for both Autonomous and Non-Autonomous Colleges, India (2006).
Awarded Second Prize for Overall Proficiency in B.Sc. Botany (Life Sciences) during the academic years 2003-2006 by Bishop Heber College, India.
Patents
Highlighted Publications
Durairaj P, Hur J-S and Yun H: Versatile biocatalysis of fungal cytochrome P450 monooxygenases. Microbial Cell Factories (2016) 15:125.
Jeon H*, Durairaj P*, Lee D, Ahsan MM and Yun H: Improved NADPH regeneration for fungal cytochrome P450 monooxygenase by co-expressing bacterial glucose dehydrogenase in resting-cell biotransformation of recombinant yeast. Journal of Microbiology and Biotechnology (2016) 26, 2076–2086. *First Author.
Durairaj P, Malla S, Nadarajan SP, Lee P-G, Jung E, Park HH, Kim B-G and Yun H: Fungal cytochrome P450 monooxygenases of Fusarium oxysporum for the synthesis of ω-hydroxy fatty acids in engineered Saccharomyces cerevisiae. Microbial Cell Factories (2015) 14:45.
Durairaj P, Jung E, Park HH, Kim B-G and Yun H: Comparative functional characterization of a novel benzoate hydroxylase cytochrome P450 of Fusarium oxysporum. Enzyme and Microbial Technology 70 (2015) 58-65.
ResearcherID Publications
Year Title Author(s) Source Volume