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Microbiology & Immunology

Microbiology & Immunology platform focus on the microbiology & immunobiology issues to support the theoretical and methodological research on key pathogenic microorganisms and their pathogenesis and immune mechanisms, and to develop the bio-products (diagnosis reagents, vaccine, adjuvants, therapeutic drug and others) to control infectious diseases. The integrated M & I analysis platform will be constructed to support the life science research and to service the human health in the future.  

QQ截图20160413150950.png

Research fields:

1.Infection immunity: Structural and functions of viral genomes;Pathogenesis, innate immunity and immune evasion mechanisms of viral infections.

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2.Microbial biology in human, animal, food, water and stress environments by epigenetics, comparative genomics and bioinformatics.

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3.Regulation and adaptive evolution of key innate immune system during in different biological evolution. Enzymology of immune cells in viral infection and inflammation.

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4.Sensing of MAMPs from bacteria, fungi, and viruses or DAMPs by immune PRRs and their compartments. Immune regulation roles of natural adjuvants (microbiota, natural components of commensal lactic acid bacteria, plants) or synthetic agonists on innate immunity.

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5.Enzymology of immune cells in viral infection and inflammation. General scheme for the enrichment of microbial cells or biomarkers with affinity probes showed as following figure.

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  • Tao Wang

    Innate immunity is the first line of host defense against invading pathogenic microorganisms, where type I interferon (IFN) production is initiated at the early stages and subsequently induces the expression of IFN-stimulated genes (ISGs) in an autocrine and paracrine manner, leading to the destruction of invading pathogens. In order to replicate and survive, viruses have evolved diverse strategies to evade IFN responses. One area of research in my laboratory is to understand the molecular mechanisms of evasion of innate immunity by pathogenic microorganisms. 

    Another goal of our research is to study the molecular mechanisms of severe fever with thrombocytopenia syndrome virus (SFTSV) and enteroviruss D68 pathogenesis.

    Key scientific issues

    1) Innate detection of viral pathogenic microorganisms;

    2) The mechanism of ubiquitin in the antiviral signaling pathway;

    3) The molecular mechanism of the generation and regulation of type I interferon and other important cytokines by natural immune activation;

    4) The mechanism of cytokine secretion after natural immune activation;

  • Jinhai Huang

    l.Molecular mechanisms on pathogenesis and immunity of viruses and bacterial toxins.

    2.The roles of cell-intrinsic restriction and recognition in innate immunity and inflammatory disease of viral infection.

    3.Development the techniques for diagnosis and prevention of human and animal pathogenic microorganisms and their toxic products in food, water, and environment.

    4.Functional genomics and engineering of resource microbes to promote human health.

  • Robert P. Borris

    The research of the Borris groups involves a) Validation of traditional medical practices, b) Discovery of novel biologically active natural products, c) Natural products used as dietary supplements, d) Phytochemical systematics, e) Application of NMR spectrometry to the structure determination of natural products, and f) Applications of high performance centrifugal partition chromatography to the isolation of biologically active natural products and other organic compounds.


  • Matthias Bureik

    The research in the Bureik group spans two primary areas: 1) Human drug metabolizing enzymes and 2) investigation of human CYP4Z1 and the treatment of breast cancer. A primary goal in the first area involves systematic testing of all variants of drug metabolizing cytochrome P450 enzymes (CYPs or P450s; see left figure below) and UDP glycosyltransferases (UGTs) identified in Chinese patients. This is expected to aid doctors in choosing the correct dosage for patients. In the second area, the group has successfully identified CYP4Z1 to be a fatty acid in-chain hydroxylase. In addition, additional substrates of this enzyme that are both structurally different and far better suited to screening procedures than fatty acids have been identified. A primary aim is to search for compounds that can act as CYP4Z1-activated prodrugs (right figure) and have potential for treatment of breast cancer.

  • Chang Chung

    The research in the Chung group focuses on understanding the role of microglia in neuroinflammation. Inflammation is a key component of pathophysiology of both acute injuries and chronic diseases including Parkinson’s and Alzheimer’s. Microglia activation/chemotaxis is prerequisite for microglia function whether neuroprotective or inflammatory, making understanding essential for design of rational approaches for therapeutic modulation and regulation of microglia proliferation and chemotaxis.  Emphasis is on control of activation/chemotaxis of resident microglia in the brain in early stages of neuroinflammation.  Unraveling complex networks of signaling downstream of P2Y12 receptor during microglia chemotaxis is an important target.  Elucidation of neurotoxic effects of microglia observed in depression is another area of research interests.

  • Benjamin Clark

    Research in the Clark group focuses on microbial natural products as applied to drug discovery, metabolomics, and chemical ecology. Microbes have long been a source of potent antimicrobial and anticancer agents, and we have a particular interest in marine and extremophilic microbes as a source of new drug leads. We also investigate chemical ecology: what role the metabolites serve for the microbe itself, and how are they involved in the interaction of microbes with other organisms. The group uses metabolic profiling and multivariate statistical techniques in all of these research avenues in order to classify samples, identify active components, and elucidate the interactions of molecules and organisms. While microbes are the primary focus of the group we also have experience working with plants and marine organisms if there are particularly interesting ecological questions to be addressed in these areas. 


  • Jun Dai

    The research efforts of the Dai group encompass two areas:  1) The role of retinoid-related orphan receptor RORα in controlling skin homeostatis, and 2) Control of normal mitosis by protein kinase haspin.  In the first area, the main interest is on the interplay between intra- and inter-cellular signaling pathways involved in control of skin tissue homeostasis and tumor development. Focuses on the role of the nuclear orphan receptor RORα in controlling keratinocyte differentiation and skin tumor formation, as well as the therapeutic potential of RORα agonists/antagonists in treatment of skin diseases.  In the second area, the group is interested in exploring the role of haspin in cancer development and the potential of haspin inhibitors as anti-tumor drugs.

  • Qingzhi Gao

    The research of the Gao group covers medicinal chemistry and molecular targeting, synthetic chemistry and organo catalysis, and computer-aided drug design, aimed at the discovery of functional drug delivery carriers and understanding mechanisms of molecular targeting. Specific areas include a) strategies for development of small molecular anti-cancer drugs for targeted therapy, b) design and development of actively transportable small molecule drugs or protein-drug conjugates, c) discovery and development of novel drug-delivery carriers and pharmaceutics based on supramolecular chemistry, d) computer aided molecular design and modeling for innovative drug discovery and mechanistic study of drug transporters.

  • Nasir Jalal

    DNA damage and repair in the realms of radiation targeting. Breast Cancer research (disease markers, radiotherapy and pre-clinical novel drugs screening). Previously worked on NASA funded cancer gap 3 project for analysis of deep space heavy ion radiation effects on human DNA.


  • Shende Jiang

    The research of the Jiang group includes, a) carbohydrate chemistry with the use of sugars as chiral starting materials in synthesis, b) studies on the shikimic acid and shikimate pathway with particular interests in designing enzyme inhibitors as potential antimicrobial agents against bacterial, fungal and parasitical pathogens, c) process research and development for Active Pharmaceutical Ingredients and related intermediates in collaboration with industry, and d) development of fluorine-18 labelled radiopharmaceuticals used in Positron Emission Tomography

  • Hyun Min Kim

    We are interested in understanding the DNA repair mechanism in the germline. Especially, we have focused on investigating the epigenetic regulation of DNA damage response and repair. We use a microscopic size nematode Caenorhabditis elegans as a model organism to study epigenetic control of DNA repair mechanism.


    1.Investigating the roles of conserved Epigenetic regulators in DNA repair and damage response.

    2.Investigating the role of novel and conserved gene of DNA repair and damage response.


    We are recuiting students. If you are interested in working hard in my laborabory, send an E-mail to me :  KimTju@QQ.com


  • Zhenli Li

    1998-2001年在天津泌尿外科研究所畅继武教授课题组所做的课题为肿瘤热休克蛋白90-肽复合物的提取纯化,并用该复合物诱导T细胞转化为特异性细胞毒性T淋巴细胞,为肿瘤的生物治疗进行基础研究。2001年继续以肿瘤特异性CTL为核心以树突状细胞转化特异性CTL为方法,进行治疗肿瘤的基础及临床应用的研究,该研究获得天津市科学技术进步奖二等奖。

  • Zhiqiang Lu

    无内容

  • Yanfang Su

    The research in the group of Su encompasses three main areas, including a) Isolation and identification of bioactive natural compounds from medicinal plants, b) Quality control of traditional chinese medicines, 3) Research & development of new medicines of natural origin

  • Jian Sun

    The research in the group of Sun involves investigation of B cell development and B cell related diseases. In recent years, immunotherapies with antibodies to depleting B cells are widely used in autoimmune diseases and B cell lymphoma. The strategy in this group is to design cytokine antagonist peptides using computer-aided design, fuse the peptides with human IgG Fc to form peptibodies by gene engineering, and analyze their activity in vitro and in vivo. Several peptibodies inhibiting B lymphocyte stimulator (BLyS), a critical factor for B cell maturation and survival, are currently tested in cell culture and SLE animal models in this lab. Because overexpression of BLyS is involved in pathogenesis and development of autoimmune diseases and B cell malignances, the BLyS antagonists designed and analyzed may be potential therapeutic reagents for these diseases.

  • Kun Zhang

    Expression and regulation of important enzymes in some metabolic pathways in microorganisms.

  • Jianyong Zhang

    The research in the group of ZHANG focuses on two areas: 1) Mechanisms of transcriptional regulation involved in canceroxidative stress response and a variety of health disorders by means of molecular biology method, 2) Mechanism study on interaction of host factors with retroelements and HIV-1 such as helicases, interferon-stimulate genes and RNA binding proteins etc.

  • Youcai Zhang

    The research in Zhang’s group focuses on the function of transporters and nuclear receptors in pharmacology and toxicology. The major projects include: 1) preclinical development of novel transporter/receptor-targeted drugs for metabolic diseases; 2) investigation of the role of intestinal microbiota in lipid metabolism; and 3) establishment of novel preclinical models to improve the prediction of drug-induced liver injury.

Microbiology & Immunology

Microbiology & Immunology platform focus on the microbiology & immunobiology issues to support the theoretical and methodological research on key pathogenic microorganisms and their pathogenesis and immune mechanisms, and to develop the bio-products (diagnosis reagents, vaccine, adjuvants, therapeutic drug and others) to control infectious diseases. The integrated M & I analysis platform will be constructed to support the life science research and to service the human health in the future.  

QQ截图20160413150950.png

Research fields:

1.Infection immunity: Structural and functions of viral genomes;Pathogenesis, innate immunity and immune evasion mechanisms of viral infections.

9.png

2.Microbial biology in human, animal, food, water and stress environments by epigenetics, comparative genomics and bioinformatics.

3.png

3.Regulation and adaptive evolution of key innate immune system during in different biological evolution. Enzymology of immune cells in viral infection and inflammation.

4.png

4.Sensing of MAMPs from bacteria, fungi, and viruses or DAMPs by immune PRRs and their compartments. Immune regulation roles of natural adjuvants (microbiota, natural components of commensal lactic acid bacteria, plants) or synthetic agonists on innate immunity.

5.png

5.Enzymology of immune cells in viral infection and inflammation. General scheme for the enrichment of microbial cells or biomarkers with affinity probes showed as following figure.

6.png

  • Tao Wang -- Leader

    Innate immunity is the first line of host defense against invading pathogenic microorganisms, where type I interferon (IFN) production is initiated at the early stages and subsequently induces the expression of IFN-stimulated genes (ISGs) in an autocrine and paracrine manner, leading to the destruction of invading pathogens. In order to replicate and survive, viruses have evolved diverse strategies to evade IFN responses. One area of research in my laboratory is to understand the molecular mechanisms of evasion of innate immunity by pathogenic microorganisms. 

    Another goal of our research is to study the molecular mechanisms of severe fever with thrombocytopenia syndrome virus (SFTSV) and enteroviruss D68 pathogenesis.

    Key scientific issues

    1) Innate detection of viral pathogenic microorganisms;

    2) The mechanism of ubiquitin in the antiviral signaling pathway;

    3) The molecular mechanism of the generation and regulation of type I interferon and other important cytokines by natural immune activation;

    4) The mechanism of cytokine secretion after natural immune activation;

  • Jinhai Huang -- Leader

    l.Molecular mechanisms on pathogenesis and immunity of viruses and bacterial toxins.

    2.The roles of cell-intrinsic restriction and recognition in innate immunity and inflammatory disease of viral infection.

    3.Development the techniques for diagnosis and prevention of human and animal pathogenic microorganisms and their toxic products in food, water, and environment.

    4.Functional genomics and engineering of resource microbes to promote human health.

  • Robert P. Borris

    The research of the Borris groups involves a) Validation of traditional medical practices, b) Discovery of novel biologically active natural products, c) Natural products used as dietary supplements, d) Phytochemical systematics, e) Application of NMR spectrometry to the structure determination of natural products, and f) Applications of high performance centrifugal partition chromatography to the isolation of biologically active natural products and other organic compounds.


  • Matthias Bureik

    The research in the Bureik group spans two primary areas: 1) Human drug metabolizing enzymes and 2) investigation of human CYP4Z1 and the treatment of breast cancer. A primary goal in the first area involves systematic testing of all variants of drug metabolizing cytochrome P450 enzymes (CYPs or P450s; see left figure below) and UDP glycosyltransferases (UGTs) identified in Chinese patients. This is expected to aid doctors in choosing the correct dosage for patients. In the second area, the group has successfully identified CYP4Z1 to be a fatty acid in-chain hydroxylase. In addition, additional substrates of this enzyme that are both structurally different and far better suited to screening procedures than fatty acids have been identified. A primary aim is to search for compounds that can act as CYP4Z1-activated prodrugs (right figure) and have potential for treatment of breast cancer.

  • Chang Chung

    The research in the Chung group focuses on understanding the role of microglia in neuroinflammation. Inflammation is a key component of pathophysiology of both acute injuries and chronic diseases including Parkinson’s and Alzheimer’s. Microglia activation/chemotaxis is prerequisite for microglia function whether neuroprotective or inflammatory, making understanding essential for design of rational approaches for therapeutic modulation and regulation of microglia proliferation and chemotaxis.  Emphasis is on control of activation/chemotaxis of resident microglia in the brain in early stages of neuroinflammation.  Unraveling complex networks of signaling downstream of P2Y12 receptor during microglia chemotaxis is an important target.  Elucidation of neurotoxic effects of microglia observed in depression is another area of research interests.

  • Benjamin Clark

    Research in the Clark group focuses on microbial natural products as applied to drug discovery, metabolomics, and chemical ecology. Microbes have long been a source of potent antimicrobial and anticancer agents, and we have a particular interest in marine and extremophilic microbes as a source of new drug leads. We also investigate chemical ecology: what role the metabolites serve for the microbe itself, and how are they involved in the interaction of microbes with other organisms. The group uses metabolic profiling and multivariate statistical techniques in all of these research avenues in order to classify samples, identify active components, and elucidate the interactions of molecules and organisms. While microbes are the primary focus of the group we also have experience working with plants and marine organisms if there are particularly interesting ecological questions to be addressed in these areas. 


  • Jun Dai

    The research efforts of the Dai group encompass two areas:  1) The role of retinoid-related orphan receptor RORα in controlling skin homeostatis, and 2) Control of normal mitosis by protein kinase haspin.  In the first area, the main interest is on the interplay between intra- and inter-cellular signaling pathways involved in control of skin tissue homeostasis and tumor development. Focuses on the role of the nuclear orphan receptor RORα in controlling keratinocyte differentiation and skin tumor formation, as well as the therapeutic potential of RORα agonists/antagonists in treatment of skin diseases.  In the second area, the group is interested in exploring the role of haspin in cancer development and the potential of haspin inhibitors as anti-tumor drugs.

  • Qingzhi Gao

    The research of the Gao group covers medicinal chemistry and molecular targeting, synthetic chemistry and organo catalysis, and computer-aided drug design, aimed at the discovery of functional drug delivery carriers and understanding mechanisms of molecular targeting. Specific areas include a) strategies for development of small molecular anti-cancer drugs for targeted therapy, b) design and development of actively transportable small molecule drugs or protein-drug conjugates, c) discovery and development of novel drug-delivery carriers and pharmaceutics based on supramolecular chemistry, d) computer aided molecular design and modeling for innovative drug discovery and mechanistic study of drug transporters.

  • Nasir Jalal

    DNA damage and repair in the realms of radiation targeting. Breast Cancer research (disease markers, radiotherapy and pre-clinical novel drugs screening). Previously worked on NASA funded cancer gap 3 project for analysis of deep space heavy ion radiation effects on human DNA.


  • Shende Jiang

    The research of the Jiang group includes, a) carbohydrate chemistry with the use of sugars as chiral starting materials in synthesis, b) studies on the shikimic acid and shikimate pathway with particular interests in designing enzyme inhibitors as potential antimicrobial agents against bacterial, fungal and parasitical pathogens, c) process research and development for Active Pharmaceutical Ingredients and related intermediates in collaboration with industry, and d) development of fluorine-18 labelled radiopharmaceuticals used in Positron Emission Tomography

  • Hyun Min Kim

    We are interested in understanding the DNA repair mechanism in the germline. Especially, we have focused on investigating the epigenetic regulation of DNA damage response and repair. We use a microscopic size nematode Caenorhabditis elegans as a model organism to study epigenetic control of DNA repair mechanism.


    1.Investigating the roles of conserved Epigenetic regulators in DNA repair and damage response.

    2.Investigating the role of novel and conserved gene of DNA repair and damage response.


    We are recuiting students. If you are interested in working hard in my laborabory, send an E-mail to me :  KimTju@QQ.com


  • Zhenli Li

    1998-2001年在天津泌尿外科研究所畅继武教授课题组所做的课题为肿瘤热休克蛋白90-肽复合物的提取纯化,并用该复合物诱导T细胞转化为特异性细胞毒性T淋巴细胞,为肿瘤的生物治疗进行基础研究。2001年继续以肿瘤特异性CTL为核心以树突状细胞转化特异性CTL为方法,进行治疗肿瘤的基础及临床应用的研究,该研究获得天津市科学技术进步奖二等奖。

  • Yanfang Su

    The research in the group of Su encompasses three main areas, including a) Isolation and identification of bioactive natural compounds from medicinal plants, b) Quality control of traditional chinese medicines, 3) Research & development of new medicines of natural origin

  • Jian Sun

    The research in the group of Sun involves investigation of B cell development and B cell related diseases. In recent years, immunotherapies with antibodies to depleting B cells are widely used in autoimmune diseases and B cell lymphoma. The strategy in this group is to design cytokine antagonist peptides using computer-aided design, fuse the peptides with human IgG Fc to form peptibodies by gene engineering, and analyze their activity in vitro and in vivo. Several peptibodies inhibiting B lymphocyte stimulator (BLyS), a critical factor for B cell maturation and survival, are currently tested in cell culture and SLE animal models in this lab. Because overexpression of BLyS is involved in pathogenesis and development of autoimmune diseases and B cell malignances, the BLyS antagonists designed and analyzed may be potential therapeutic reagents for these diseases.

  • Kun Zhang

    Expression and regulation of important enzymes in some metabolic pathways in microorganisms.

  • Jianyong Zhang

    The research in the group of ZHANG focuses on two areas: 1) Mechanisms of transcriptional regulation involved in canceroxidative stress response and a variety of health disorders by means of molecular biology method, 2) Mechanism study on interaction of host factors with retroelements and HIV-1 such as helicases, interferon-stimulate genes and RNA binding proteins etc.

  • Youcai Zhang

    The research in Zhang’s group focuses on the function of transporters and nuclear receptors in pharmacology and toxicology. The major projects include: 1) preclinical development of novel transporter/receptor-targeted drugs for metabolic diseases; 2) investigation of the role of intestinal microbiota in lipid metabolism; and 3) establishment of novel preclinical models to improve the prediction of drug-induced liver injury.