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Youcai Zhang——Associate Professor

Room A506, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
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Education Experience
2011 Ph. D. University of Kansas Medical Center, KA, USA
2011 Postdoctoral Elan Pharma, Inc., CA; 2013, Apricity, Inc. &
Professional Experience
Research Area

The research in Zhang’s group focuses on the function of transporters and nuclear receptors in pharmacology and toxicology. The major projects include: 1) preclinical development of novel transporter/receptor-targeted drugs for metabolic diseases; 2) investigation of the role of intestinal microbiota in lipid metabolism; and 3) establishment of novel preclinical models to improve the prediction of drug-induced liver injury.


Honors and Awards
Highlighted Publications
Zhang Y.; Limaye P. B.; Renaud, H. J.; Klaassen C. D. Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. Toxicol. Appl. Pharmacol. 2014, 277, 138.
Zhang Y.; Csanaky I. L.; Selwyn F. P.; Lehman-McKeema, L. D.; Klaassen C. D. Organic anion transporting polypeptide 1a4 is important for secondary bile acid metabolism. Biochem. Pharmacol. 2013, 86, 437.
Zhang Y.; Hong J. Y.; Rockwell C. E.; Copple B.; Jaeschke H.; Klaassen C. D. Effect of bile duct ligation on bile acid metabolism and liver toxicity in mice. Liver Internat. 2012, 32, 58.
Zhang Y.; Csanaky I. L.; Lehman-McKeeman L. D.; Klaassen C. D. Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid hepatotoxicity in mice by increasing intestinal permeability. Toxicol. Sci. 2011, 124, 251.
Zhang Y.; Klaassen C. D. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J. Lipid Res. 2010, 51, 3230.
ResearcherID Publications
Year Title Author(s) Source Volume