Home / People / / Youcai Zhang

Youcai Zhang——Associate Professor

Nationality:
CHINA
Phone:
022-87401830
Email:
youcai.zhang@tju.edu.cn
Office:
Room A506, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
2011 Ph. D. University of Kansas Medical Center, KA, USA
2011 Postdoctoral Elan Pharma, Inc., CA; 2013, Apricity, Inc. &
Professional Experience
Research Area

The research in Zhang’s group focuses on the function of transporters and nuclear receptors in pharmacology and toxicology. The major projects include: 1) preclinical development of novel transporter/receptor-targeted drugs for metabolic diseases; 2) investigation of the role of intestinal microbiota in lipid metabolism; and 3) establishment of novel preclinical models to improve the prediction of drug-induced liver injury.

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Honors and Awards
Patents
Highlighted Publications
Zhang Y.; Limaye P. B.; Renaud, H. J.; Klaassen C. D. Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. Toxicol. Appl. Pharmacol. 2014, 277, 138.
Zhang Y.; Csanaky I. L.; Selwyn F. P.; Lehman-McKeema, L. D.; Klaassen C. D. Organic anion transporting polypeptide 1a4 is important for secondary bile acid metabolism. Biochem. Pharmacol. 2013, 86, 437.
Zhang Y.; Hong J. Y.; Rockwell C. E.; Copple B.; Jaeschke H.; Klaassen C. D. Effect of bile duct ligation on bile acid metabolism and liver toxicity in mice. Liver Internat. 2012, 32, 58.
Zhang Y.; Csanaky I. L.; Lehman-McKeeman L. D.; Klaassen C. D. Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid hepatotoxicity in mice by increasing intestinal permeability. Toxicol. Sci. 2011, 124, 251.
Zhang Y.; Klaassen C. D. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J. Lipid Res. 2010, 51, 3230.
ResearcherID Publications
Year Title Author(s) Source Volume
2015 Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice. Selwyn, Felcy Pavithra; Csanaky, Ivan L; Zhang, Youcai; et al. Drug metabolism and disposition: the biological fate of chemicals 43
2015 Prediction and validation of enzyme and transporter off-targets for metformin Yee, Sook Wah; Lin, Lawrence; Merski, Matthew; et al. Journal of Pharmacokinetics and Pharmacodynamics 42
2014 Decreased Bile-Acid Synthesis in Livers of Hepatocyte-Conditional NADPH-Cytochrome P450 Reductase-Null Mice Results in Increased Bile Acids in Serum Cheng, Xingguo; Zhang, Youcai; Klaassen, Curtis D. Journal of Pharmacology and Experimental Therapeutics 351
2014 Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice Zhang, Youcai; Limaye, Pallavi B.; Renaud, Helen J.; et al. Toxicology and Applied Pharmacology 277
2014 OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin Chen, Ligong; Shu, Yan; Liang, Xiaomin; et al. Proceedings of the National Academy of Sciences of the United States of America 111
2013 Hormonal regulation of Cyp4a isoforms in mouse liver and kidney Zhang, Youcai; Klaassen, Curtis D. Xenobiotica 43
2013 Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice Liu, Jie; Lu, Yuan-Fu; Zhang, Youcai; et al. Toxicology and Applied Pharmacology 272
2013 Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism Zhang, Youcai; Csanaky, Ivan L.; Selwyn, Felcy Pavithra; et al. Biochemical Pharmacology 86
2013 Reduced Renal Clearance of Cefotaxime in Asians with a Low-Frequency Polymorphism of OAT3 (SLC22A8) Yee, Sook Wah; Anh Nguyet Nguyen; Brown, Chaline; et al. Journal of Pharmaceutical Sciences 102
2012 Dysfunction of Organic Anion Transporting Polypeptide 1a1 Alters Intestinal Bacteria and Bile Acid Metabolism in Mice Zhang, Youcai; Limaye, Pallavi B.; Lehman-McKeeman, Lois D.; et al. Plos One 7
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