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Rajavel Srinivasan——Associate Professor

Room 506, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
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Education Experience
2009 Ph. D. National University of Singapore, Singapore
2010-2013 Postdoctoral University of Cambridge, United Kingdom
Professional Experience
2013-2016 Scientist I Singapore's Agency for Science, Technology, and Research, ICES
Research Area

The research in the group of Srinivasan encompasses two main areas, 1) Developing new reaction methodologies: The research topics under this area include bioorthogonal reactions, late-stage modification of advanced chemical entities, C-H activation, and high-throughput amenable synthesis – aiming at advancing the way organic molecules are made for drug discovery and chemical biology applications. 2) Inhibitor discovery based on fragment-based approaches: Design and synthesis of ‘unconventional’ fragments with rich structural diversity. These fragments will be used as a starting point towards novel inhibitors for unexplored biological targets such as the AurB-INCENP interaction.


Honors and Awards
TOP Graduate Researcher - Faculty of Science, National University of Singapore, Singapore, 2007
Best Graduate Researcher - Department of Chemistry, National University of Singapore, Singapore 2007
Highlighted Publications
Resmi, CP.; Coyne, A.G.; Srinivasan R. Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines? Curr. Med. Chem. 2018, doi: 10.2174/0929867324666170727120315
Srinivasan, R.; Coyne, A. G.; Abell, C. Regioselective Conversion of Arenes to N-aryl-1,2,3-triazoles Using C-H Borylation. Chem. Eur. J. 2014, 20, 11680.
Sinivasan, R.; Tan, L. P.; Wu, H.; Yang, P.-Y.; Kalesh, K. A.; Yao, S. Q. High-Throughput Synthesis of Azide Libraries Suitable for Direct “Click”Chemistry and in situ Screening. Org. Biomol. Chem. 2009, 7, 1821.
Srinivasan, R.; Tan, L. P.; Hao, W.; Yao, S. Q. Solid-Phase Assembly and in situ Screening of Protein Tyrosine Phosphatases inhibitors. Org. Lett. 2008, 10, 2295.
Srinivasan, R.; Li, J.; Ng, S. L.; Kalesh, K. A.; Yao, S. Q. Methods of Using Click Chemistry in the Discovery of Enzyme Inhibitors. Nature Protocols 2007, 2, 2655.
Srinivasan, R.; Uttamchandani, M.; Yao, S. Q. Rapid Assembly and In Situ Screening of Bidentate Inhibitors of Protein Tyrosine Phosphatases (PTPs). Org. Lett. 2006, 8, 713.
ResearcherID Publications
Year Title Author(s) Source Volume
2016 Divergent Synthesis of Dihydroxanthene-Hemicyanine Fused Near-Infrared Fluorophores through the Late-Stage Amination of a Bifunctional Precursor Ong, Michelle Jui Hsien; Srinivasan, Rajavel; Romieu, Anthony; et al. Organic Letters 18
2015 An amidation/cyclization approach to the synthesis of N-hydroxyquinolinones and their biological evaluation as potential anti-plasmodial, anti-bacterial, and iron(II)-chelating agents Teng, Yanbo; Suwanarusk, Rossarin; Ngai, Mun Hong; et al. Bioorganic & Medicinal Chemistry Letters 25
2014 Regioselective Conversion of Arenes to N-aryl-1,2,3-triazoles Using C-H Borylation Srinivasan, Rajavel; Coyne, Anthony G.; Abell, Chris Chemistry-a European Journal 20
2009 High-Throughput Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (MptpB) Inhibitors Using Click Chemistry Tan, Lay Pheng; Wu, Hao; Yang, Peng-Yu; et al. Organic Letters 11
2009 High-throughput synthesis of azide libraries suitable for direct "click" chemistry and in situ screening Srinivasan, Rajavel; Tan, Lay Pheng; Wu, Hao; et al. Organic & Biomolecular Chemistry 7
2009 Site-specific covalent labeling of proteins inside live cells using small molecule probes Chattopadhaya, Souvik; Srinivasan, Rajavel; Yeo, Dawn S. Y.; et al. Bioorganic & Medicinal Chemistry 17
2008 Click synthesis of small-molecule inhibitors targeting caspases Ng, Su Ling; Yang, Peng-Yu; Chen, Kitty Y. -T.; et al. Organic & Biomolecular Chemistry 6
2008 In vivo imaging of a bacterial cell division protein using a protease-assisted small-molecule labeling approach Chattopadhaya, Souvik; Abu Bakar, Farhana B.; Srinivasan, Raiavel; et al. Chembiochem 9
2008 Solid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors Srinivasan, Rajavel; Tan, Lay Pheng; Wu, Hao; et al. Organic Letters 10
2008 Solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases Yang, Peng-Yu; Wu, Hao; Lee, Mei Yin; et al. Organic Letters 10
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