Home / People / / Rajavel Srinivasan

Rajavel Srinivasan——Associate Professor

Room 506, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
Group weblink
Education Experience
2009 Ph. D. National University of Singapore, Singapore
2010-2013 Postdoctoral University of Cambridge, United Kingdom
Professional Experience
2013-2016 Scientist I Singapore's Agency for Science, Technology, and Research, ICES
Research Area

The research in the group of Srinivasan encompasses two main areas, 1) Developing new reaction methodologies: The research topics under this area include bioorthogonal reactions, late-stage modification of advanced chemical entities, C-H activation, and high-throughput amenable synthesis – aiming at advancing the way organic molecules are made for drug discovery and chemical biology applications. 2) Inhibitor discovery based on fragment-based approaches: Design and synthesis of ‘unconventional’ fragments with rich structural diversity. These fragments will be used as a starting point towards novel inhibitors for unexplored biological targets such as the AurB-INCENP interaction.


Honors and Awards
TOP Graduate Researcher - Faculty of Science, National University of Singapore, Singapore, 2007
Best Graduate Researcher - Department of Chemistry, National University of Singapore, Singapore 2007
Highlighted Publications
Srinivasan, R.; Coyne, A. G.; Abell, C. Regioselective Conversion of Arenes to N-aryl-1,2,3-triazoles Using C-H Borylation. Chem. Eur. J. 2014, 20, 11680.
Sinivasan, R.; Tan, L. P.; Wu, H.; Yang, P.-Y.; Kalesh, K. A.; Yao, S. Q. High-Throughput Synthesis of Azide Libraries Suitable for Direct “Click”Chemistry and in situ Screening. Org. Biomol. Chem. 2009, 7, 1821.
Srinivasan, R.; Tan, L. P.; Hao, W.; Yao, S. Q. Solid-Phase Assembly and in situ Screening of Protein Tyrosine Phosphatases inhibitors. Org. Lett. 2008, 10, 2295.
Srinivasan, R.; Li, J.; Ng, S. L.; Kalesh, K. A.; Yao, S. Q. Methods of Using Click Chemistry in the Discovery of Enzyme Inhibitors. Nature Protocols 2007, 2, 2655.
Srinivasan, R.; Uttamchandani, M.; Yao, S. Q. Rapid Assembly and In Situ Screening of Bidentate Inhibitors of Protein Tyrosine Phosphatases (PTPs). Org. Lett. 2006, 8, 713.
ResearcherID Publications
Year Title Author(s) Source Volume