Home / People / / Jun Dai

Jun Dai ——Associate Professor

Nationality:
CHINA
Phone:
022-87401830
Email:
jun.dai@tju.edu.cn
Office:
Room A303, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
2000 Ph. D. Tulane University, LA
2000 Postdoctoral Brigham and Womens Hospital, Boston, MA
Professional Experience
2008-2014 Instructor in Dermatology Massachusetts General Hospital/Harvard Medical School
2005-2008 Instructor in Medicine Brigham and Women’s Hospital/Harvard Medical School
2000-2005 Postdoctoral Fellow Brigham and Women’s Hospital, Boston, MA
Research Area

The research efforts of the Dai group encompass two areas:  1) The role of retinoid-related orphan receptor RORα in controlling skin homeostatis, and 2) Control of normal mitosis by protein kinase haspin.  In the first area, the main interest is on the interplay between intra- and inter-cellular signaling pathways involved in control of skin tissue homeostasis and tumor development. Focuses on the role of the nuclear orphan receptor RORα in controlling keratinocyte differentiation and skin tumor formation, as well as the therapeutic potential of RORα agonists/antagonists in treatment of skin diseases.  In the second area, the group is interested in exploring the role of haspin in cancer development and the potential of haspin inhibitors as anti-tumor drugs.

1.jpg2.jpg

Honors and Awards
Patents
Highlighted Publications
Dai, J.; Brooks, Y.; Lefort, K.; Getsios, S.; Dotto, G. P. The retinoid-related orphan receptor RORα promotes keratinocyte differentiation via FOXN1. PLoS ONE 2013, 8, e70392.
Wang, F.; Dai, J.; Daum, J. R.; Niedzialkowska E.; Banerjee B.; Stukenberg T.; Gorbsky G. J.; Higgins, J. M. Histone H3 Thr-3 phosphorylation by haspin positions Aurora B at centromeres in mitosis. Science 2010, 330, 231.
Dai, J.; Kateneva, A. V.; Higgins, J. M. Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion. J. Cell Sci. 2009, 122, 4148.
Dai, J.; Sullivan, B. A.; Higgins, J. M. Regulation of mitotic chromosome cohesion by haspin and aurora B. Dev. Cell 2006; 11, 741. (Featured cover illustration)
Dai, J.; Sultan, S.; Taylor, S. S.; Higgins, J. M. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes & Dev. 2005, 19, 472. (Featured cover illustration)
ResearcherID Publications
Year Title Author(s) Source Volume