Home / People / / Janak Pathak

Janak Pathak——Assistant Professor

Nationality:
Nepalese
Phone:
13752138262
Email:
j.pathak@tju.edu.cn
Office:
206B/Building 24, 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China
School:
School of Pharmaceutical Science and Technology
ResearcherID:
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Education Experience
2011-2015 Ph. D. Bone biology, osteoimmunology KU Leuven, Belgium and VU University Amsterdam, Th
2008-2011 M.S. Biochemistry and Molecular, Tongji Medical College
2002-2006 Bachelor Medical Laboratory Technology Institute of Medicine, Tribhuvan University Teach
Professional Experience
2005-2008 Instructor Institute of Medical Education, Kathmandu, Nepal
2006-2007 Laboratory quality control officer Siddhi Polyclinic Research Lab, Kathmandu,Nepal
2011-2015 PhD researcher Dept Oral Cell Biology, ACTA-UvA& VU, Amsterdam, The Netherlands, and Skeletal Biology and Engin
Research Area

Research Interest: Osteoimmunology, bone biology, osteoporosis, tissue engeneering (bone and cartilage regeneration)


My research is mainly focus on to unravle the mechanism of systemic inflammation-induced osteoporosis. 

Fig: Mechanism of inflammation-induced osteoporosis

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Honors and Awards
Charles D. Tenney International Postdoctoral Fellowship (2015-2017)
Erasmus Mundus Joint Doctorate (EMJD) PhD Fellowship (2011-2015)
China Scholarship Council fellowship for Master Degree Study (2007-2011)
ECTS East-Meet-West Award 2016, 43rd European Calcified Tissue Congress, Rome, 2016
New Investigator Award 2015 for highest scoring abstract entitled “Mechanical loading reduces inflammation-induced human osteocyte-to-osteoclast communication” selected for oral communication at 4th Joint Meeting of European Calcified Tissue (ECTS) and International Bone and Mineral Society (IBMS), 25-28 April, 2015.
Bone travel Grant 2015 by Dutch Society for Calcium for attending 4th Joint Meeting of European Calcified Tissue and International Bone and Mineral Society, 25-28 April, 2015.
MOVE Award 2015 for the best publication entitled “Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts” at the 6th Annual MOVE Research Meeting, VU University Amsterdam, The Netherlands, Feb 4, 2015.
Charles D. Tenney International Fellow to Participate School of Pharmaceutical Science and Technology (SPST’s) Symposium on Direction in Modern Sciences 2014.
Ditan International Travel Grant Award to attend the 4thDitan International Conference on Infectious Diseases, Jul 15-18, 2010, Beijing, China. IBFF International Travel Award to attend 12th International Bone Fluid Flow (IBFF) workshop, Houston, Texas, USA, Sep 10-11, 2014.
American Association for Clinical Chemistry (AACC) International Travel Grant to attend the AACC Annual Meeting in Atlanta, GA, USA, Jul 24-28, 2011.
Gallwas 5 Year Membership Grant (2011-2015) forthe American Association for Clinical Chemistry (AACC).
American Association for Clinical Chemistry (AACC) International Travel Grant to attend the AACC Annual Meeting in Philadelphia, USA, Jul 31-Aug 4, 2016.
Patents
Highlighted Publications
Ran J, Zeng H, Pathak JL, Jiang P, Bai Y, Yan P, Sun G, Shen X, Tong H, Shi B. Constructing Anisotropic Triple-Pass Tubular Framework within Lyophilized Porous Gelatin (GEL) Scaffold Using Dexamethasone (DEX)-Loaded Functionalized Whatman Paper (FP) to Reinforce Its Mechanical Strength and Promote Osteogenesis. Biomacromolecules. 2017 Oct 9. doi: 10.1021/acs.biomac.7b00673. [Epub ahead of print]
Liu L#, Pathak JL#, Yong-qiang Zhu YQ, Matthias Buriek M*. Cytochrome P450s expression in four different human oseoblast models. Biological chemistry (in press).
Dong Y, Ye H, Liu Y, Xu L, Wu Z, Hu X, Ma J, Pathak JL*, Liu J*, Wu G. pH dependent silver nanoparticle releasing titanium implant: A novel therapeutic approach to control peri-implant infection. Colloid and Surfaces B-biointerfaces 2017 158:127–136.
Gutha Y, Pathak JL, Zhang W, Zhang Y, Xu J*. Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/Zinc oxide beads (CS/PVA/ZnO). International Journal of Biological Macromolecules, 2017; pii: S0141-8130(17)30933-9.
Liu J, Zeng Y, Shi S, Xu L, Zhang H, Pathak JL*, Pan Y*. Design of poly-aspartic acid peptide-poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone. International Journal of Nanomedicine 2017;12:3561–3575. IF-4.3
Liu T , Zheng Y, Wu G, Wismeijer D, Yuelian Pathak JL*, Liu Y*. BMP2 coprecipitated calcium phosphate granules enhance osteoinductivity of deproteinized bovine bone, and bone formation during critical-sized bone defect healing. Scientific Reports 2017;7:41800 | DOI: 10.1038/srep41800. IF-5.5
Chung CY, Yu S, Surendranath AR, Jalal N, Pathak JL, Subramaniyam S. Role of calcium-independent phospholipase A2 (iPLA2) VIA in mediating neurological disorder and cancer. Transaction of Tianjin University 2017;23(1):1-10. 2016.
Jin Y, Xu L, Hu X, Liao S, Pathak JL*, Liu J*: Lithium Chloride Enhances Bone Regeneration and Implant Osseointegration in Osteoporotic Condition. J Bone Miner Metab. 2016 Oct 6 [Epub ahead of print]. DOI: 10.1007/s00774-016-0783-6. IF-2.8
Li D, Wan Q, Pathak JL, Li Z*: Platelet-derived growth factor-BB enhances osteoclast formation and osteoclasts precursor cell chemotaxis. J Bone Miner Metab. 2016 Sep 14 [Epub ahead of print]. DOI: 10.1007/s00774-016-0773-8. IF-2.8
Jalal N*, Richard AR, Pathak JL, Chung CY, “Bisphenol-A: The mighty and the mutagenic.” Submitted to Journal of Cancer Research and Therapeutics, 2016.
Shah K, Stern M, Stern A, Pathak JL, Bravenboer N, and Astrid Bakker A*: Osteocytes isolation and culture methods. Bonekey Rep. 2016 Sep 14;5:838. doi: 10.1038/bonekey.2016.65. eCollection 2016.
Pathak JL, Verschueren P, Lems WF, N, Klein-Nulend J, Bakker AD, Luyten FP: Serum of patients with active rheumatoid arthritis inhibits differentiation of osteochondrogenic precursor cells. Connect Tissue Res 2016;57(3):226-235. IF-1.8
Pathak JL, Bakker AD, Luyten FP, Verschueren P, Lems WF, Klein-Nulend J, Bravenboer N: Systemic inflammation affects human osteocyte-specific protein and cytokine expression. Calcif Tissue Int 2016;98(6):596-608. IF-3.3
Pathak JL, Bakker AD, Verschueren P, Lems WF, Luyten FP, Klein-Nulend J, Bravenboer N: CXCL8 and CCL20 enhance osteoclastogenesis via modulation of cytokine production by human primary osteoblasts. PLoS One 2015;10:e0131041. IF-3.5
Pathak JL, Bravenboer N, Luyten FP, Verschueren P, Lems WF, Klein-Nulend J, Bakker AD: Mechanical loading reduces inflammation-induced human osteocyte-to-osteoclast communication. Calcified Tissue International 2015;97:169-178. IF-3.3
Pathak JL, Bravenboer N, Verschueren P, Lems WF, Luyten FP, Klein-Nulend J, Bakker AD: Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts. Osteoporosis International 2014;25:2453-2463. IF-4.2
ResearcherID Publications
Year Title Author(s) Source Volume