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Lizhi Mi——Professor

Building 15, Rm 324, Tianjin University
School of Life Sciences
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Education Experience
1987-1991 Bachelor of Science Physics Peking University
1993-1996 M.S. Biophysics Tsinghua University
1997-2004 Ph. D. Biophysics University of Virginia
2004-2005 Postdoctoral Pharmacology University of Virginia
2005-2014 Postdoctoral Structural Biology Harvard Medical School
Professional Experience
1991-1991 Teaching Assistant Tianjin Sino-German Vocational Institute of Technology
1996-1997 Research Assistant Tsinghua University
2014-2016 Professer Tianjin University
Research Area

We are interested in the structural and mechanistic basis of developmental signaling that are important in stem cell biology, cancer metastasis, and regenerative medicine. At structural levels, we want to understand: how developmental signaling molecules are regulated by extracellular micro-environment, how these molecules are recognized by cell surface receptors, and how these molecules are engaged with intracellular signaling cascades through lipid bilayer. At functional levels, we focus on understanding how ligand isoforms are distinguished by their targeted cells to generate distinct cellular outcomes, and how developmental signaling is involved in stem cell self-renewal and differentiation. Eventually, we want to explore potentials in therapeutic development against cancer and other human diseases.

Honors and Awards
Thousand Talents Program (Youth Talent), Tianjin, China 2014
Dean’s Fellowship, University of Virginia, 1997–1999
“Yiqi Mei” Fellowship, Tsinghua University, China, 1995
Highlighted Publications
Li-Zhi Mi, Srikripa Devarakonda, Joe M. Harp, Qing Han, Roberto Pellicciari, Timothy M. Willson, Sepideh Khorasanizadeh, Fraydoon Rastinejad Structure basis for binding and activation of the bile acid receptor FXR Mol Cell 200311(4):1093-1100
John F. Flanagan*, Li-Zhi Mi*, Maksymilian Chruszcz, Marcin Cymborowski, Katrina L. Clines, Youngchang Kim, Wladek Minor, Fraydoon Rastinejad, Sepideh Khorasanizadeh Double chromodomains cooperate to recognize the methylated histone H3 tail Nature 2005 438(7071):1181-5 (*equal contribution)
Li-Zhi Mi*, Michael J. Grey*, Noritaka Nishida, Thomas Walz, Chafen Lu, Timothy A. Springer Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs Biochemistry 2008 47(39):10314-10323 (*equal contribution)
Li-Zhi Mi, Chafen Lu, Zongli Li, Noritaka Nishida, Thomas Walz, Timothy A. Springer Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor Nat Struct Mol Biol 2011 18(9):984-9
Li-Zhi Mi, Christopher T. Brown, Yijie Gao, Yuan Tian, Viet Le, Thomas Walz, Timothy A. Springer Structure of bone morphogenetic protein 9 procomplex PNAS 2015 112(12):3710-5
ResearcherID Publications
Year Title Author(s) Source Volume
1997 Interaction of rabbit C-reactive protein with phospholipid monolayers studied by microfluorescence film balance with an externally applied electric field. Mi, L Z; Wang, H W; Sui, S F Biophysical journal 73
1999 Calcium-dependent binding of rabbit C-reactive protein to supported lipid monolayers containing exposed phosphorylcholine group Sui, SF; Sun, YT; Mi, LZ Biophysical Journal 76
1999 Efficient coupled and high sensitive broadband IR waveguide sensor Mi, LZ; Braiman, MS Biophysical Journal 76
2001 Large scale production of nuclear receptor ligand-binding domains. Mi, L Z; Rastinejad, F Methods in molecular biology (Clifton, N.J.) 176
2000 Mid-IR evanescent-wave sensors for tiny biological samples Shilov, SV; Braiman, MS; Mi, LZ; et al. Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques 3918
2003 Structural basis for bile acid binding and activation of the nuclear receptor FXR Mi, LZ; Devarakonda, S; Harp, JM; et al. Molecular Cell 11
2005 Double chromodomains cooperate to recognize the methylated histone H3 tail Flanagan, JF; Mi, LZ; Chruszcz, M; et al. Nature 438
2004 Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor Wright, CS; Mi, LZ; Rastinejad, F Journal of Molecular Biology 342
2005 Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: Evidence for hydrolase activity Wright, CS; Mi, LZ; Lee, S; et al. Biochemistry 44
2008 Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs Mi, Li-Zhi; Grey, Michael J.; Nishida, Noritaka; et al. Biochemistry 47
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