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Haoran Guo ——Lecturer

Room206, Buliding15,Tianjin University
School of Life Sciences
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Education Experience
2003-2007 B.Sc. College of Pharmacy,Pharmacy Jilin University
2007-2010 M.S. College of Pharmacy, Pharmaceutical chemistry Jilin University
2010-2013 Ph. D. College of First Clinical Hospital,Biochemistry an Jilin University
Professional Experience
2009-2010 Pharmaceutical analysis researcher WuXi AppTec Company/Department of Pharmaceutical analysis
2013-2013 Lecturer Tianjin University/School of Life sciences
Research Area

The research my group lies at the interaction of virus and host proteins, such as the interaction of accessory protein of HIV-1,HIV-2 and SIV with host protein of E3 ligase,SAMHD1 and so on, another study is about molecular epidemiology of virus, including Enterovirus 71A and Coxsackievirus A16.

1.A novel motif  in Vpx and Vpr of HIV/SIV was identified which is critical for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest.

2.In the study of circulating HFMD-Associated Coxsackievirus A16, we found that it is genetically and phenotypically distinct from the prototype CV-A16.

3.Map the founction region of host protein SAMHD1 which is critical for nuclear localization and Vpx-Mediated degradation.

Honors and Awards
Highlighted Publications
5.Wei Wei, HaoranGuo, Xianjun Liu, Hong Zhang, Lei Qian, Kun Luo,Richard Markham and Xiao-Fang Yu* .A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation[J].Journal of Virology, 2014, 88(1):745-51.
4.Wei Wei#, HaoranGuo#, Xue Han, Xianjun Liu, Xiaohong Zhou,Wenyan Zhang, Xiao-Fang Yu*. A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest[J]. Cellular Microbiology, 2012,14(11):1745-1756.
3.HaoranGuo, Wei Wei, Zhenhong Wei, Xianjun Liu, Sean L. Evans, WeimingYang,Hong Wang, Ying Guo, Ke Zhao, Jian-Ying Zhou, Xiao-Fang Yu*.Identification of Critical Regions in Human SAMHD1 Required for Nuclear Localization and Vpx-Mediated Degradation[J]. Plos One, 2013, 8(7):e66201.
2.Wei Wei#, HaoranGuo#, Jingliang Li, Sangsang Ren, Zhenhong Wei, WanguoBao, Xiaoming Hu,Ke Zhao, Wenyan Zhang, Yulai Zhou, Fei Sun, Richard Markham and Xiao-Fang Yu*. Circulating HFMD-Associated Coxsackievirus A16 is genetically and phenotypically distinct from theprototype CV-A16. [J]Plos One. 2014 Apr 15;9(4):e94746. doi: 10.1371/journal.pone.0094746.
1.Xianjun Liu#, HaoranGuo#, Hong Wang, Richard Markham, Wei Wei*, Xiao-Fang Yu*.HIV-1 Vpr suppresses the cytomegalovirus promoter in a CRL4(DCAF1) E3 ligase independent manner. [J] Biochemical and Biophysical Research Communications.2015 Feb 19. pii: S0006-291X(15)00288-0. doi: 10.1016/j.bbrc.2015.02.060.
ResearcherID Publications
Year Title Author(s) Source Volume