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Michael Yuchi——Associate Professor

Room 506, Building 24, Tianjin University
School of Pharmaceutical Science and Technology
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Education Experience
1999-2003 Bachelor of Science Life Sciences Fudan University
2003-2009 Ph. D. Biochemistry and Biomedical Sciences McMaster University
2009-2010 Postdoctoral Cold Spring Harbour Laboratory
2010-2015 Postdoctoral Biochemistry and Molecular Biology University of British Columbia
Professional Experience
2015-2016 Research Associate University of British Columbia
2015- Joint Professor Fujian Agriculture and Forestry University
2016- Associate Professor Tianjin University
Research Area

The research of Yuchi’s group centers on the structure and function of ion channels. Ion channels are the second largest target class for approved drugs. Drugs targeting ion channels are used to treat arrhythmia, neuropathic pain, epilepsy, anxiety and more. The ultimate goal of our group is to understand the physiological and pathological roles of ion channels at the molecular level. The specific questions we are tackling include: 1) the interaction network and regulation of ion channels involved in heart and muscle diseases; 2) how disease-causing mutations perturb the structure and function of critical ion channels; 3) how to target insect ion channels to develop novel biopesticides. To answer these questions, our lab combines a variety of complementary techniques, including X-ray crystallography, electrophysiology, calorimetry, in-silico drug screening, as well as many other biochemical, biophysical and computational methods. 


Channel Regulation at High Resolution613074.jpg

Disease-causing Mutations in Ion Channel

Honors and Awards
Gordon Research Conference Best Presentation 2015
Michael John Page Postdoctoral Fellow Award 2014
Michael Smith Postdoctoral Fellowship 2013
Highlighted Publications
Yuchi, Z., and Van Petegem, F. (2016) Ryanodine Receptors under the Magnifying Lens: insights and limitations from current cryo-electron microscopy and X-ray crystallography studies. Cell Calcium, 59, 209-227
Yuchi, Z., Wong King Yuen, S.M., Lau, K., Underhill, A., Cornea, R., Fessenden, J.D., and Van Petegem, F. (2015) Crystal structures of Ryanodine Receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant. Nature Communications 6:7947 doi: 10.1038/ncomms8947
Yuchi, Z., Lau, K., and Van Petegem, F. (2012) Disease mutations in the Ryanodine Receptor Central Region: Crystal structures of a phosphorylation hot spot domain. Structure 20, 1201-1211
Yuchi, Z., and Van Petegem, F. (2011) Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors. Channels 5, 120-123
Yuchi, Z., Pau, V. P., Lu, B.X., Junop, M., and Yang, D.S. (2009) An engineered right-handed coiled coil domain imparts extreme thermostability to the KcsA channel. FEBS J 276, 6236-6246
Yuchi, Z., Pau, V. P., and Yang, D. S. (2008) GCN4 enhances the stability of the pore domain of potassium channel KcsA. FEBS J 275, 6228-6236
ResearcherID Publications
Year Title Author(s) Source Volume