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Nasir Jalal——Assistant Professor

Nationality:
Pakistan
Phone:
+86(155)1095-1246
Email:
nasirjalal@tju.edu.cn
Office:
B-203 Building 24, Tianjin University, 92 Weijin Road, Tianjin
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
2015-2017 Postdoctoral Molecular Pharmacology Tianjin University, China
2007-2012 Ph. D. Cell and Molecular Biology Colorado State University, USA
1994-1996 Master of Science Botany University of the Punjab, Pakistan
1992-1994 Bachelor of Science Pre-medical University of the Punjab, Pakistan
Professional Experience
2015-2017 Charles Tenney Post-doctoral fellow Tianjin University, China
2012-2014 Assistant Professor National University of Sciences and Technology, Pakistan
2010-2012 Student scientist Colorado State University, USA
2003-2007 Assistant Professor Forman Christian University, Pakistan
Research Area


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Primary Focus: Radiation Induced Bystander Mutagenesis (RIBE)

Top: Construction of E-18 cell line (a modified WTK1 cell line) to measure bystander mutagenesis at a higher resolution. A unique 18 base sequence spliced into the TK1 gene of heterozygous host; which upon exogenous expression of the I-Sce1 restriction enzyme cuts at the 18 base sequence and renders a heterozygous cell line to homozygous recessive for the TK1 gene. Such recessive mutants can be screened using the mutation assay. Poisson distribution analysis allows the measurement of mutants in a 96 well assay to determine mutation frequency.  

Bottom: Comet assay employed for semi-quantification of  I-Sce1 induced DNA damage in E-18 cells using fluorescence microscopy.


Other research interests:

Collaborating in the field of translational breast cancer research that is focused on identifying environmental risks, conceiving new therapeutic strategies, testing novel anti-cancer drugs and providing insight to develop new prototypes of biomedical equipment for in-vitro fertilization technology and tailored gene therapy. Also, interested in the screening of novel synthetic lead compounds (such as Akt 1, 2, 3) that have therapeutic potential against cancer target proteins.



Honors and Awards
Charles D. Tenney post doctoral fellow (2015-2017)
William J. Fulbright scholar (2007-2012)
Griswold scholarship (2011)
Best graduate student leader award (2011)
Valedictorian M.Sc session (1996)
Best graduate student leader award_Colorado State Univ (2011)
President Council of International Student Affairs_Colorado State Univ (2010-2012)
Patents
Highlighted Publications
Noreen Akhtar, Ishrat Jabeen*, Nasir Jalal, Jon Antilla. (2018) Structure-Based Pharmacophore Models to Probe Anticancer Activity of Inhibitors of Protein Kinase B-beta (PKB β). Chemical Biology & Drug Design. DOI: 10.1111/cbdd.13418. Accepted Oct 21, 2018.
Humaira Sawal, Kashif Asghar, Matthias Bureik, Nasir Jalal. * (2017) Bystander signaling via oxidative metabolism. Oncotargets and Therapy 10:3925-3940. https://doi.org/10.2147/OTT.S136076

Bilal Zulfiqar, Kaenat Nasir, Amnah Mahroo, Rai Khalid Farooq, Nasir Jalal, Gui-Bo Yang, Muhammad Usman Rashid, Kashif Asghar, Muhammad Ali A Shah,* (2017) Nanomedicine and cancer immunotherapy targeting indoleamine 2, 3-dioxygenase. OncoTargets and Therapy 2017:10 463–476. https://www.dovepress.com/nanomedicine--and--cancer--immunotherapy--focus--on--indoleamine--23--- peer-reviewed-article-OTT
Nasir Jalal*, Austin R. Surendranath, Janak L. Pathak, Shi Yu, Chang Y. Chung. (2017) “Bisphenol A: the mighty and the mutagenic.” Toxicology Reports ISSN: 2214-7500, https://doi.org/10.1016/j.toxrep.2017.12.013 Science Direct Publishing group.
Faria Khan; Naeem Akhtar; Nasir Jalal; Irshad Hussain; Rafal Szmigielski; Muhammad Qasim Hayat; Hafiz B. Ahmad; Waleed A. El-Said; Minghui Yang; Hussnain A. Janjua. (2017) "Biocompatible, Non-enzymatic Photo-electrochemical Sensor for Selective Monitoring of H2O2 Released from HeLa Cells." (In Press with Microchimica Acta, Springer Journals)
Uzair Hashmi, Faria Khan, Asad Abdullah Shahid, Aqib Javed, Tehseen Alam, Nasir Jalal, Qasim Hayat, Hussnain A. Janjua. (2017) Hydrogels incorporated with silver nanocolloids prepared from antioxidant rich Aerva javanica as disruptive agents against burn wound infections. Colloids and Surfaces A: Physicochemical and Engineering Aspects. Volume 529, 20 September 2017, Pages 475-486 (http://dx.doi.org/10.1016/j.colsurfa.2017.06.036).
Venkatrao Nunna, Nasir Jalal, Matthias Bureik.* (2017) Anti-CYP4Z1 autoantibodies detected in breast cancer patients. Cellular & Molecular Immunology 14:1–3. doi:10.1038/cmi.2017.21, Nature publishing group. http://www.nature.com/cmi/journal/vaop/ncurrent/full/cmi201721a.html
Nasir Jalal (2017) Use of E18 Cell Model to Quantify DNA Strand Break Associated Bystander Effect (DSB-ABE). J Carcinogene Mutagene 8:295. doi: 10.4172/2157-2518.1000295. https://www.omicsonline.org/open-access/use-of-e18-cell-model-to-quantify-dna-strand-break-associated-bystander-effect-dsbabe-2157-2518-1000295.php?aid=89754
ResearcherID Publications
Year Title Author(s) Source Volume
2015 Contemplating the Importance of Toll-like Receptors I and II Regarding Human Viral Pathogenesis Saeed, Umar; Mazoor, Sobia; Jalal, Nasir; et al. Jundishapur Journal of Microbiology 8
2014 Radiation induced bystander effect and DNA damage Jalal, Nasir; Haq, Saba; Anwar, Namrah; et al. Journal of Cancer Research and Therapeutics 10
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