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Dan Ma——

B201, Building 24,92 Weijin Road, Nankai DistrictTianjin, 300072, P. R. China
School of Pharmaceutical Science and Technology
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Education Experience
2016-2018 Postdoctoral Structural Biology University of British Columbia
2013-2016 Ph. D. Ecology Nankai University
2008-2011 M.S. Botany Tianjin Normal University
2004-2008 B.Sc. Biological engineering Tianjin University of Commerce
Professional Experience
2011-2013 Assistant Researcher Tianjin Tianshi Biological Development CO.,LTD
Research Area

Structure and function research of ion channels that act as insecticide targets. Nowadays, ion channels remain the primary targets of many the small molecule insecticides. Voltage-gated sodium (NaV) channels are responsible for the generation and propagation of action potentials in excitable cells and play an important role in insect physiology. However, so far, the binding sites and the molecular mechanism for the modes of actions of these pesticides remain elusive, hindering the improvement of the pesticides based on the rational design. In 2017, Nieng Yan’s group has been solved the structure of a putative NaV channel from American cockroach at 3.8 angstrom resolution by Cryo-EM . The near–atomic resolution structure of this eukaryotic NaV channel establishes an important foundation for investigating the function and disease mechanisms of NaV channels and for structure-guided drug development . Although atomic structures of NaV provides a structural template for the modeling and virtual docking of known pesticides, the accurate binding modes are still not clear. In my future project, I plan to study the complex structures of the insect sodium channel bound with known pesticides by cryo-EM. 

Honors and Awards
Highlighted Publications
Jie Liu#, Dan Ma#, Lili Ma, Yuhao Song, Guanghai Gao, Yingying Wang. Geographic distribution pattern of low and high nucleic acid content bacteria on a river-catchment scale[J]. Marine and Freshwater Research.2017,68,1618-1625.
Dan Ma, Rui Sun, Wei quan, Yingying Wang. Microbial degradation pathway of dibutylphthalate by a typical ultramicrobacterium and the expression and purification of 4-oxalomesaconate hydratase[J].Journal of Agro-Environmental Science,2016, 35(10): 1992-1997.
Dan Ma, Zhenyu Hao, Rui Sun, Mark Bartlam, and Yingying Wang . Genome Sequence of a Typical Ultramicrobacterium, Curvibacter sp. Strain PAE-UM, Capable of Phthalate Ester Degradation[J]. Genome announcements.2016,4(1).
Dan Ma, Mark Bartlam & Yingying Wang*. The crystal structure of phthalate dioxygenase reductase protein from a typical ultramicrobacteria PAE-UM.13th Symposium on Bacterial Genetics and Ecology (BAGECO),2015,06:232.
ResearcherID Publications
Year Title Author(s) Source Volume