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Home / Seminar & Event /Upcoming Events / (312) 1,2,3-Triazole Derivatives as Novel Fluorescence Probe
(312) 1,2,3-Triazole Derivatives as Novel Fluorescence Probe
Seminar: (312) 1,2,3-Triazole Derivatives as Novel Fluorescence Probe
Speaker: Prof. Xiaodong Shi, Department of Chemistry, University of South Florida, Tampa, USA
Time: 2018-06-16 09:00 to 2018-06-16 10:00
Venue: Meeting room (406), Building 24
Organizer:

Prof. Jon Antilla 


Abstract: Small organic molecule fluorophores have attracted increasing attention in chemistry, biology, material science and dye industry. However, effective UV/blue-light-emitting small molecule fluorophores are rare due to the relative high energy gap required betweenthe interactive orbitals, which may cause either poor photostability or low quantum efficiency. In recent years, our group has developed the synthesis and functionalization of 1,2,3-triazole and found that N-2-aryl-triazole (NAT) displays excellent fluorescence emission in the high energy UV/blue region. G-quadruplex is one of the unique self assembled structure found in nature. It has been developed as an interesting supramolecular motif for ion-selective membrane channels, self-assembled nanowires and supramolecular hydrogel. Taking advantage of the electron deficiency of 1,2,3-triazole and electron rich guanosine, we designed a triazole substituted guanosine and successfully achieved high fluorescent intensity which can be used in the application of molecular switch and biological probe. Both structurally novel and functional enriched G-quartets are achieved using this new system. Potential applications in molecular sensing and biological target recognition are expected with this new system.


Shi-CV.pdf


(312) 1,2,3-Triazole Derivatives as Novel Fluorescence Probe
Seminar: (312) 1,2,3-Triazole Derivatives as Novel Fluorescence Probe
Speaker: Prof. Xiaodong Shi, Department of Chemistry, University of South Florida, Tampa, USA
Time: 2018-06-16 09:00 to 2018-06-16 10:00
Venue: Meeting room (406), Building 24
Organizer:

Prof. Jon Antilla 


Abstract: Small organic molecule fluorophores have attracted increasing attention in chemistry, biology, material science and dye industry. However, effective UV/blue-light-emitting small molecule fluorophores are rare due to the relative high energy gap required betweenthe interactive orbitals, which may cause either poor photostability or low quantum efficiency. In recent years, our group has developed the synthesis and functionalization of 1,2,3-triazole and found that N-2-aryl-triazole (NAT) displays excellent fluorescence emission in the high energy UV/blue region. G-quadruplex is one of the unique self assembled structure found in nature. It has been developed as an interesting supramolecular motif for ion-selective membrane channels, self-assembled nanowires and supramolecular hydrogel. Taking advantage of the electron deficiency of 1,2,3-triazole and electron rich guanosine, we designed a triazole substituted guanosine and successfully achieved high fluorescent intensity which can be used in the application of molecular switch and biological probe. Both structurally novel and functional enriched G-quartets are achieved using this new system. Potential applications in molecular sensing and biological target recognition are expected with this new system.


Shi-CV.pdf