Study Sheds Light on the Mechanism of Diamide Insecticides and Associated Resistance
2024/11/18
Recently, a research team led by Professor Yuchi Zhiguang from Tianjin University, along with collaborators, published a study in Nature Communications titled "Cryo-EM Structures of Ryanodine Receptors and Diamide Insecticides Reveal the Mechanisms of Selectivity and Resistance" (https://doi.org/10.1038/s41467-024-53490-0).Insects demonstrate extraordinary adaptability in dynamic ecosystems, th...
SPST Faculty Develop Novel Ferroptotis-Targeting Ovarian Cancer Therapy
2024/10/08
Ferroptosis has been recognized as a promising therapeutic strategy for cancer due to its unique mechanism of action. However, the upregulation of stearoyl-CoA desaturase 1 (SCD1) in ovarian cancer leads to resistance to ferroptotic therapy. Zinc ion (Zn2+) serves as the cofactor of SCD1. It was hypothesized that selective deprivation of Zn2+ from SCD1 could sensitize ferroptotic ovarian cancer...
2024/09/09
The 29th Annual International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Conference was held in Atlanta, USA from May 5th to 8th, 2024. Our team of health and pharmacy administration was invited to attend. Dr. Xie Shitong, associate researcher at our school, presented a invited oral report titled "The Development of the China Health Related Outcomes Measures: Generic Version (C...
2024/09/03
On August 21-23, 2024, the 2024 International Value-Based Healthcare Conference was held in Singapore. Prof. Wu Jing, vice secretary (in charge of party affairs) and vice president of SPST, and Dr. Xie Shitong, associate researcher in the Department of health and pharmacy administration, attended the conference as special guests. They also engaged in academic exchanges with top international un...
Jiuzhoutong Pharmaceutical Co., Ltd visited SPST
2024/09/02
On August 1st, 2024, Jiuzhoutong Pharmaceutical Co., Ltd. Visited SPST, accompanied by Dean of SPST, Liu Xiuyun, and the Deputy Dean of SPST, Du Yunfei.Through exchanges and research, both sides look forward to further enhancing exchanges and cooperation and jointly assisting the health industry.
Delegation of Indian Scientists Visits SPST
2024/09/02
On June 28th, a delegation of Indian scientists consisting Professor Soumyajit Roy of India Academy of Science, Education and Research, Kolkata; Dr. Nageswara Rao Pulipati of Bycus Therapeutics Pvt. Ltd, India; Professor Kalpesh Vasant Bhavsar of National Centre for Nanoscience and Nanotechnology, University of Mumbai; Mr. Vithal Kumar.L, manager of technology transfer office, IKP Knowledge Par...
Professor Gao Wenyuan’s Team Makes Progress in the Biological Control of Astragalus Memeranaceus
2024/03/11
Recently, the team of Professor Gao Wenyuan in the School of Pharmaceutical Science and Technology (SPST) of Tianjin University developed biological antifungal agent for root rot. The relevant research is published on Chemical Engineering Journal as "ZnO-S.cerevisiae: An effective growth promoter of Astragalus memeranaceus and nano-antifungal agent against Fusarium oxysporum".Su Yaowu, master s...
SPST Faculty Develop Novel Ferroptptic Melanoma Therapy
2024/02/26
Ferroptotic cancer therapy has been extensively investigated since the coining of the ferroptosis concept. However, the therapeutic efficacy of ferroptosis induction in heterogeneous and plastic melanoma has been compromised because the melanocytic and transitory cell subpopulation is resistant to iron-dependent oxidative stress. The Research Group at SPST recently reported a phenotype-altering...
2024/02/06
Following surgery, tumor recurrence is a common concern that can be managed through immunotherapy. Nevertheless, the efficacy of such therapy is restricted. Emerging research has indicated that cellular pyroptosis may trigger long-lasting hyperinflammation, which can assist the immune system in effectively eliminating tumor cells over an extended period. Consequently, upholding the localized mi...
Reversing Ferroptosis Resistance in Breast Cancer via Tailored Lipid and Iron Presentation
2023/12/11
Cancer resistance is often associated with the presence of persister cells and the polarization of cancer cells towards a mesenchymal state. Therefore, ferroptotic cancer therapy has gained extensive attention because it is potent to eradicate resistant cancers that are refractory to conventional apoptosis-based approaches. Tailored phospholipids (arachidonoyl phosphatidylethanolamine/PE-AA) ar...
