Professor Gao Wenyuan’s Team Makes Progress in the Biological Control of Astragalus Memeranaceus
2024/03/11
Recently, the team of Professor Gao Wenyuan in the School of Pharmaceutical Science and Technology (SPST) of Tianjin University developed biological antifungal agent for root rot. The relevant research is published on Chemical Engineering Journal as "ZnO-S.cerevisiae: An effective growth promoter of Astragalus memeranaceus and nano-antifungal agent against Fusarium oxysporum".Su Yaowu, master s...
SPST Faculty Develop Novel Ferroptptic Melanoma Therapy
2024/02/26
Ferroptotic cancer therapy has been extensively investigated since the coining of the ferroptosis concept. However, the therapeutic efficacy of ferroptosis induction in heterogeneous and plastic melanoma has been compromised because the melanocytic and transitory cell subpopulation is resistant to iron-dependent oxidative stress. The Research Group at SPST recently reported a phenotype-altering...
2024/02/06
Following surgery, tumor recurrence is a common concern that can be managed through immunotherapy. Nevertheless, the efficacy of such therapy is restricted. Emerging research has indicated that cellular pyroptosis may trigger long-lasting hyperinflammation, which can assist the immune system in effectively eliminating tumor cells over an extended period. Consequently, upholding the localized mi...
Reversing Ferroptosis Resistance in Breast Cancer via Tailored Lipid and Iron Presentation
2023/12/11
Cancer resistance is often associated with the presence of persister cells and the polarization of cancer cells towards a mesenchymal state. Therefore, ferroptotic cancer therapy has gained extensive attention because it is potent to eradicate resistant cancers that are refractory to conventional apoptosis-based approaches. Tailored phospholipids (arachidonoyl phosphatidylethanolamine/PE-AA) ar...
SPST Teacher Attends 7th National Academic Conference on Analytical Pharmacology
2023/11/09
From October 20 to 22, the 7th National Academic Conference on Analytical Pharmacology was held in Hangzhou. Dr. Xiangjun Meng, an associate professor from School of Pharmaceutical Science and Technology, Tianjin University, was invited to attend this conference.The conference was organized by the Analytical Pharmacology Committee of the Chinese Pharmacological Society. With the theme of "Towar...
2023/11/09
Heavy metal pollution has become a significant global environmental issue, with lead being one of the primary contaminants. Lead pollution primarily originates from human activities, particularly mining, manufacturing, and the combustion of fossil fuels, which releases lead into the environment and ultimately poses risks to human health. However, issues such as long-term exposure to lead and ot...
Using Probiotics to Alleviate Insulin Resistance Uncovers New Treatment Pathways
2023/11/03
Insulin resistance plays a key role in type 2 diabetes research, and a high-sugar diet is often considered one of its main triggers. Recently, Professor Wang Yiwen’s research team at the School of Pharmaceutical Science and Technology successfully used the fruit fly (Drosophila melanogaster), as a model to explore the potential role of gut microbiota in insulin resistance.The study results sho...
2023/10/26
Chiral recognition is an important topic in modern drug research. Two enantiomers of chiral drugs may present different pharmacodynamics and pharmacokinetic properties. For example, one enantiomer has pharmacological activity, while the other is less active or even toxic. The physical and chemical properties of the two enantiomers are very similar, and their separation directly depends on the c...
15th SPST Sub-session of 2023 Doctoral Academic Forum of Tianjin University Held
2023/10/23
On October 19, 2023 Doctoral Academic Forum of Tianjin University opened in the lecture hall on the second floor of Science Library.Prof. Chang Jin and Prof. Zhang Xiaodong (Forum Supervisors from Tianjin University), Secretary of the Party Committee of the School of Pharmaceutical Science and Technology (SPST) Zhang Ling, Vice Party Secretary Li Nan, Associate Deans of SPST Peter Robert Taylor...
2023/10/16
Among known click chemistry, sulfur(VI) fluoride exchange (SuFEx) reaction, a new generation click chemistry, in which the S–F bond reacts readily with silyl-protected phenols, phenolates or amines. In 2019, Han Zuilhof’s group discovered that SuFEx reaction is intrinsically enantiospecific click reaction as a chiral S(VI) center reacts exclusively with inversion of configuration. The SuFEx r...
